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The relative amounts of alpha-amd beta-globin mRNA and globin gene DNA were measured in reticulocyte RNA and lymphocyte DNA of an individual with homozygous hereditary persistence of fetal hemoglobin whose red blood cells contain 100% fetal hemoglobin (hb F: alpha2gamma2.) Molecular hybridization assays used as probes full-length DNA copies of human alpha- and beta-globin messenger RNA. The results of these hybridization assays demonstrated the expected amounts of alpha-globin mRNA and gene DNA, but absence of beta-globin mRNA and absence of beta-globin gene DNA. In the individual studied, hereditary persistence of fetal hemoglobin is associated with total deletion of the beta-globin structural gene.
B G Forget, and
D G Hillman, and
H Lazarus, and
E F Barell, and
J R Benz ej, and
C T Caskey, and
T H Huisman, and
W A Schroeder, and
D Housman
January 1989,
Hemoglobin,
B G Forget, and
D G Hillman, and
H Lazarus, and
E F Barell, and
J R Benz ej, and
C T Caskey, and
T H Huisman, and
W A Schroeder, and
D Housman
April 1982,
Blood,
B G Forget, and
D G Hillman, and
H Lazarus, and
E F Barell, and
J R Benz ej, and
C T Caskey, and
T H Huisman, and
W A Schroeder, and
D Housman
September 1988,
Human genetics,
B G Forget, and
D G Hillman, and
H Lazarus, and
E F Barell, and
J R Benz ej, and
C T Caskey, and
T H Huisman, and
W A Schroeder, and
D Housman
January 2009,
American journal of hematology,
B G Forget, and
D G Hillman, and
H Lazarus, and
E F Barell, and
J R Benz ej, and
C T Caskey, and
T H Huisman, and
W A Schroeder, and
D Housman
August 1974,
The Journal of clinical investigation,
B G Forget, and
D G Hillman, and
H Lazarus, and
E F Barell, and
J R Benz ej, and
C T Caskey, and
T H Huisman, and
W A Schroeder, and
D Housman
February 1974,
Nature,
B G Forget, and
D G Hillman, and
H Lazarus, and
E F Barell, and
J R Benz ej, and
C T Caskey, and
T H Huisman, and
W A Schroeder, and
D Housman
January 1990,
Annals of the New York Academy of Sciences,
B G Forget, and
D G Hillman, and
H Lazarus, and
E F Barell, and
J R Benz ej, and
C T Caskey, and
T H Huisman, and
W A Schroeder, and
D Housman
January 1989,
Progress in clinical and biological research,
B G Forget, and
D G Hillman, and
H Lazarus, and
E F Barell, and
J R Benz ej, and
C T Caskey, and
T H Huisman, and
W A Schroeder, and
D Housman
February 1990,
Blood,
B G Forget, and
D G Hillman, and
H Lazarus, and
E F Barell, and
J R Benz ej, and
C T Caskey, and
T H Huisman, and
W A Schroeder, and
D Housman
January 1996,
Acta haematologica,
