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Storage of single-donor platelets is currently limited to 5 days. During this period, however, numerous morphologic and biochemical changes have been observed. The present study describes increased binding of anti-GMP 140 to stored single-donor platelet concentrates; this reveals a progressive activation process. In contrast, when stored platelets are stimulated with ADP, GMP 140, expression is reduced indicating a diminished release reaction. Additionally, the GP IIb/IIIa receptor complex and its fibrinogen-induced binding site (LIBS1) are reduced by storage time, demonstrating a diminished fibrinogen binding. Further experiments have to clarify whether these changes observed in vitro translate into a reduced hemostatic capacity after transfusion in vivo.
M Böck, and
M Gawaz, and
M U Heim, and
W Mempel
January 2005,
Clinical chemistry and laboratory medicine,
M Böck, and
M Gawaz, and
M U Heim, and
W Mempel
April 1999,
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M Böck, and
M Gawaz, and
M U Heim, and
W Mempel
April 1996,
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M Böck, and
M Gawaz, and
M U Heim, and
W Mempel
December 1993,
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M Böck, and
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W Mempel
August 2011,
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M Böck, and
M Gawaz, and
M U Heim, and
W Mempel
April 1991,
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
M Böck, and
M Gawaz, and
M U Heim, and
W Mempel
March 2023,
Vox sanguinis,
M Böck, and
M Gawaz, and
M U Heim, and
W Mempel
January 2006,
Transfusion,
M Böck, and
M Gawaz, and
M U Heim, and
W Mempel
August 1987,
British journal of haematology,
M Böck, and
M Gawaz, and
M U Heim, and
W Mempel
April 1988,
British journal of haematology,
