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A new polymeric biomaterial that contains covalently bound iodine, and is therefore radiopaque, was used to construct a sustained local drug-delivery device. A polymeric wall was designed to be porous (i.e., passage of low-molecular-weight molecules across the wall is possible), self-healing, and biocompatible. Once implanted, the sphere cavity can be filled and refilled with a concentrated solution of a (cytostatic) drug, which is subsequently released by slow diffusion into the tissue region surrounding the sphere. This principle of sustained local drug delivery is shown by a series of in vitro experiments on the release of 5-fluorouracil, and in vivo animal experiments, using x-ray fluoroscopic and scintigraphic techniques.
L H Koole, and
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N E van 't Oost, and
M J van Kroonenburgh, and
F H van der Veen
January 2021,
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N E van 't Oost, and
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F H van der Veen
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F H van der Veen
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International journal of molecular sciences,
L H Koole, and
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M J van Kroonenburgh, and
F H van der Veen
November 1989,
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L H Koole, and
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F H van der Veen
June 2018,
Nature biomedical engineering,
L H Koole, and
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M J van Kroonenburgh, and
F H van der Veen
July 2015,
Bioconjugate chemistry,
