Biomaterial Database

Corneal endothelial cell changes in pseudoexfoliation syndrome after cataract surgery. 1998

C Wirbelauer, and N Anders, and D T Pham, and J Wollensak

Augenklinik im Virchow-Klinikum, Medizinische Fakultät der Humboldt-Universität zu Berlin, Germany. cwirbelauer@pc2.ophtha.mu-luebeck.de

OBJECTIVE To characterize possible differences in endothelial cell changes after cataract surgery in patients with pseudoexfoliation syndrome (PSX). METHODS In this prospective, age-matched, controlled clinical study, 25 consecutive patients with PSX and 25 control patients with senile cataracts only were studied. All patients were treated with standardized cataract surgery. Sequential quantitative and qualitative morphometric endothelial cell analyses of the central and paracentral cornea were performed preoperatively and postoperatively at 1 day, 4 weeks, and 6 months using noncontact specular microscopy. RESULTS Preoperative endothelial cell counts were 9.9% (P<.05) lower in patients with PSX (2387+/-266 cells/mm2) than in controls (2648+/-349 cells/mm2). The mean endothelial cell loss was 11.1% in the PSX group and 10.3% (P<.001 for both) in the control group, with no intergroup differences after 6 months. The mean endothelial cell area increased in both groups. Also, qualitative analysis revealed no significant differences in the endothelial repair mechanisms. CONCLUSIONS Endothelial cell density is reduced preoperatively in patients with PSX compared with age-matched controls. In patients with PSX, cataract surgery induced similar endothelial cell changes without increased endothelial cell loss postoperatively.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D011446	Prospective Studies	Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.	Prospective Study,Studies, Prospective,Study, Prospective
D002452	Cell Count	The number of CELLS of a specific kind, usually measured per unit volume or area of sample.	Cell Density,Cell Number,Cell Counts,Cell Densities,Cell Numbers,Count, Cell,Counts, Cell,Densities, Cell,Density, Cell,Number, Cell,Numbers, Cell
D004728	Endothelium, Corneal	Single layer of large flattened cells covering the surface of the cornea.	Anterior Chamber Epithelium,Corneal Endothelium,Endothelium, Anterior Chamber,Epithelium, Anterior Chamber,Anterior Chamber Endothelium
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D017889	Exfoliation Syndrome	The deposition of flaky, translucent fibrillar material most conspicuous on the anterior lens capsule and pupillary margin but also in both surfaces of the iris, the zonules, trabecular meshwork, ciliary body, corneal endothelium, and orbital blood vessels. It sometimes forms a membrane on the anterior iris surface. Exfoliation refers to the shedding of pigment by the iris. (Newell, Ophthalmology, 7th ed, p380)	Glaucoma Capsulare,Pseudoexfoliation Syndrome,Exfoliation Glaucoma,Exfoliative Syndrome,Pseudo-Exfoliation Syndrome,Pseudoexfoliation Of The Lens,Exfoliation Syndromes,Exfoliative Syndromes,Pseudo Exfoliation Syndrome,Pseudo-Exfoliation Syndromes,Pseudoexfoliation Syndromes,Syndrome, Exfoliation,Syndrome, Exfoliative,Syndrome, Pseudo-Exfoliation,Syndrome, Pseudoexfoliation,Syndromes, Exfoliation,Syndromes, Exfoliative,Syndromes, Pseudo-Exfoliation,Syndromes, Pseudoexfoliation
D018918	Phacoemulsification	A procedure for removal of the crystalline lens in cataract surgery in which an anterior capsulectomy is performed by means of a needle inserted through a small incision at the temporal limbus, allowing the lens contents to fall through the dilated pupil into the anterior chamber where they are broken up by the use of ultrasound and aspirated out of the eye through the incision. (Cline, et al., Dictionary of Visual Science, 4th ed & In Focus 1993;1(1):1)	Phacoemulsifications
D019654	Lens Implantation, Intraocular	Insertion of an artificial lens to replace the natural CRYSTALLINE LENS after CATARACT EXTRACTION or to supplement the natural lens which is left in place.	Implantation, Intraocular Lens,Implantations, Intraocular Lens,Intraocular Lens Implantation,Intraocular Lens Implantations,Lens Implantations, Intraocular