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Hypokalaemia is a clinical phenomenon in patients with acute myeloid leukaemia (AML) to which activation of the renin-angiotensin system (RAS) may contribute. Recently monocytes were found to express renin, the key initializing enzyme of the RAS. By RT/PCR, transcripts for renin were detected in four of 18 bone marrow samples from patients with AML. Three leukaemic cell lines, isolated monocytes, bone marrow stromal cells and 25 peripheral blood and 24 bone marrow samples of normal controls were negative for renin transcripts. In view of the importance of local RAS in other tissues, the expression of renin in the bone marrow of AML patients warrants further investigation.
G G Wulf, and
G Jahns-Streubel, and
R Nobiling, and
F Strutz, and
B Hemmerlein, and
W Hiddemann, and
B Wörmann
May 1986,
British journal of haematology,
G G Wulf, and
G Jahns-Streubel, and
R Nobiling, and
F Strutz, and
B Hemmerlein, and
W Hiddemann, and
B Wörmann
September 2000,
Cytokines, cellular & molecular therapy,
G G Wulf, and
G Jahns-Streubel, and
R Nobiling, and
F Strutz, and
B Hemmerlein, and
W Hiddemann, and
B Wörmann
January 2010,
British journal of haematology,
G G Wulf, and
G Jahns-Streubel, and
R Nobiling, and
F Strutz, and
B Hemmerlein, and
W Hiddemann, and
B Wörmann
June 2009,
British journal of haematology,
G G Wulf, and
G Jahns-Streubel, and
R Nobiling, and
F Strutz, and
B Hemmerlein, and
W Hiddemann, and
B Wörmann
July 2018,
British journal of haematology,
G G Wulf, and
G Jahns-Streubel, and
R Nobiling, and
F Strutz, and
B Hemmerlein, and
W Hiddemann, and
B Wörmann
January 2019,
Folia biologica,
G G Wulf, and
G Jahns-Streubel, and
R Nobiling, and
F Strutz, and
B Hemmerlein, and
W Hiddemann, and
B Wörmann
January 1988,
Leukemia research,
G G Wulf, and
G Jahns-Streubel, and
R Nobiling, and
F Strutz, and
B Hemmerlein, and
W Hiddemann, and
B Wörmann
August 2021,
EJHaem,
G G Wulf, and
G Jahns-Streubel, and
R Nobiling, and
F Strutz, and
B Hemmerlein, and
W Hiddemann, and
B Wörmann
July 2023,
British journal of haematology,
G G Wulf, and
G Jahns-Streubel, and
R Nobiling, and
F Strutz, and
B Hemmerlein, and
W Hiddemann, and
B Wörmann
December 2014,
British journal of haematology,
