Biomaterial Database

[The significance of leukotrienes in pathophysiology of bronchial asthma--therapy perspectives]. 1997

P Wojnowski, and J Patkowski

Katedra i Klinika Chorób Wewnetrznych i Alergologii Akademii Medycznej we Wrocławiu.

Leukotrienes, products of the 5-lipoxygenase pathway of arachidonic acid, are pro-inflammatory mediators with various biological activities, including mechanisms relevant to the pathogenesis of bronchoobturation in bronchial asthma. This article reviews the evidence on their role in the pathophysiology of asthma as well as on the efficacy of recently developed antileukotriene agents. Leukotriene receptor antagonists and synthesis of inhibitors show promise as a new pharmacologic approach to the treatment of this disease.

UI	MeSH Term	Description	Entries
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001249	Asthma	A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	Asthma, Bronchial,Bronchial Asthma,Asthmas
D015289	Leukotrienes	A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.	Leukotriene
D018077	Receptors, Leukotriene	Cell-surface receptors that bind LEUKOTRIENES with high affinity and trigger intracellular changes influencing the behavior of cells. The leukotriene receptor subtypes have been tentatively named according to their affinities for the endogenous leukotrienes LTB4; LTC4; LTD4; and LTE4.	Leukotriene Receptors,Receptors, SRS-A,SRS-A Receptors,Leukotriene Receptor,Receptors, Leukotrienes,SRS-A Receptor,Slow Reacting Substance of Anaphylaxis Receptors,Slow Reaction Substance of Anaphylaxis Receptors,Leukotrienes Receptors,Receptor, Leukotriene,Receptor, SRS-A,Receptors, SRS A,SRS A Receptor,SRS A Receptors
D020024	Leukotriene Antagonists	A class of drugs designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level.	Leukotriene Antagonist,Leukotriene Receptor Antagonist,Leukotriene Receptor Antagonists,Antagonists, Leukotriene,Receptor Antagonists, Leukotriene,Antagonist, Leukotriene,Antagonist, Leukotriene Receptor,Antagonists, Leukotriene Receptor,Receptor Antagonist, Leukotriene