Biomaterial Database

[The effect of halothane and enflurane as well as of propanidid and ketamin on the aortic baroreceptor discharge of decerebrated cats (author's transl)]. 1976

W Hagenau, and D Pietsch, and J O Arndt

The effect of halothane, enflurane, propanidid and ketamine on the sensitivity of the aortic baroreceptors and its quantitative relationship with arterial pressure were studied in decerebrated cats. Receptor response curves (single baroreceptor fibres of the depressor nerve) were constructed by plotting the average discharge rate (spikes/sec) against the aortic mean pressure and the effect of the anaesthetics on them was analysed. The blood pressure was changed over wide ranges by inflating a balloon placed in the thoracic part of the descending aorta through a femoral artery. Receptor sensitivity increased with halothane and enflurane, yet it decreased with propanidid. It remained uneffected duringanesthesia with ketamine. Thus, different anesthetics act differently on the afferent impulse traffic of baroreceptors. The possible role of these effects on blood pressure control during anaesthesia is discussed.

UI	MeSH Term	Description	Entries
D007649	Ketamine	A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.	2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone,CI-581,Calipsol,Calypsol,Kalipsol,Ketalar,Ketamine Hydrochloride,Ketanest,Ketaset,CI 581,CI581
D008738	Methyl Ethers	A group of compounds that contain the general formula R-OCH3.	Ethers, Methyl
D011311	Pressoreceptors	Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.	Baroreceptors,Receptors, Stretch, Arterial,Receptors, Stretch, Vascular,Stretch Receptors, Arterial,Stretch Receptors, Vascular,Arterial Stretch Receptor,Arterial Stretch Receptors,Baroreceptor,Pressoreceptor,Receptor, Arterial Stretch,Receptor, Vascular Stretch,Receptors, Arterial Stretch,Receptors, Vascular Stretch,Stretch Receptor, Arterial,Stretch Receptor, Vascular,Vascular Stretch Receptor,Vascular Stretch Receptors
D011410	Propanidid	An intravenous anesthetic that has been used for rapid induction of anesthesia and for maintenance of anesthesia of short duration. (From Martindale, The Extra Pharmacopoeia, 30th ed, p918)	Epontol,Panitol,Sombrevin
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002404	Catheterization	Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.	Cannulation,Cannulations,Catheterizations
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D003655	Decerebrate State	A condition characterized by abnormal posturing of the limbs that is associated with injury to the brainstem. This may occur as a clinical manifestation or induced experimentally in animals. The extensor reflexes are exaggerated leading to rigid extension of the limbs accompanied by hyperreflexia and opisthotonus. This condition is usually caused by lesions which occur in the region of the brainstem that lies between the red nuclei and the vestibular nuclei. In contrast, decorticate rigidity is characterized by flexion of the elbows and wrists with extension of the legs and feet. The causative lesion for this condition is located above the red nuclei and usually consists of diffuse cerebral damage. (From Adams et al., Principles of Neurology, 6th ed, p358)	Decerebrate Posturing,Decorticate Rigidity,Decorticate State,Rigidity, Decerebrate,Rigidity, Decorticate,Decerebrate Posturings,Decerebrate Rigidity,Decerebrate States,Decorticate Rigidities,Decorticate States,Posturing, Decerebrate,Posturings, Decerebrate,Rigidities, Decorticate,State, Decerebrate,States, Decerebrate
D004737	Enflurane	An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.	Alyrane,Enfran,Enlirane,Ethrane,Etran
D005263	Femoral Artery	The main artery of the thigh, a continuation of the external iliac artery.	Common Femoral Artery,Arteries, Common Femoral,Arteries, Femoral,Artery, Common Femoral,Artery, Femoral,Common Femoral Arteries,Femoral Arteries,Femoral Arteries, Common,Femoral Artery, Common

Related Publications

W Hagenau, and D Pietsch, and J O Arndt

[The effect of methohexital, fentanyl, droperidol, and chloralose on the aortic baroceptor discharge of decerebrated cats (author's transl)].

January 1978, Der Anaesthesist,

W Hagenau, and D Pietsch, and J O Arndt

[Comparison of halothane and enflurane on the pulmonary compliance (author's transl)].

January 1981, Anesthesie, analgesie, reanimation,

W Hagenau, and D Pietsch, and J O Arndt

[Effect of enflurane (ethrane) on intracranial pressure in comparison with halothane (author's transl)].

July 1976, Der Anaesthesist,

W Hagenau, and D Pietsch, and J O Arndt

[The effects of halothane and enflurane on uterine activity during childbirth (author's transl)].

February 1978, Praktische Anasthesie, Wiederbelebung und Intensivtherapie,

W Hagenau, and D Pietsch, and J O Arndt

[Experiences gained with a combined ketamin anaesthesia for eye-surgery on cats (author's transl)].

February 1977, Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology,

W Hagenau, and D Pietsch, and J O Arndt

Influence of halothane on control of breathing in intact and decerebrated cats.

August 1987, Journal of applied physiology (Bethesda, Md. : 1985),

W Hagenau, and D Pietsch, and J O Arndt

[Alteration of the volatile anaesthetics halothane and enflurane in heated humidifiers (author's transl)].

August 1981, Der Anaesthesist,

W Hagenau, and D Pietsch, and J O Arndt

[Pharmacological studies on propanidid (author's transl)].

January 1972, Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina,

W Hagenau, and D Pietsch, and J O Arndt

[Effects of halothane on the peripheral nervous conduction in cats (author's transl)].

September 1980, Masui. The Japanese journal of anesthesiology,