Catch-up primary vaccination with acellular pertussis vaccines in 3-4-year-old children--reactogenicity and serological response. 1998

O Wärngård, and L Nilsson, and C Fåhraeus, and L Gustafsson, and H O Hallander, and P Olin, and J Storsaeter
Department of Paediatrics, Norrköping Hospital, Sweden.

In order to evaluate the optimum number of doses for catch-up primary vaccination against pertussis, 248 Swedish children 3-4 years of age were randomized to receive either two or three doses of a three-component or a five-component acellular pertussis vaccine. Adverse reactions were mild, but increased with increasing number of doses, especially in a subgroup of 17 children with serological signs of earlier pertussis. There were no clinically significant differences between the two vaccines. Antibody levels against pertussis were higher after two doses in this age group than after three doses in infancy. A primary vaccination program for older children can use two instead of three doses.

UI MeSH Term Description Entries
D007115 Immunization Schedule Schedule giving optimum times usually for primary and/or secondary immunization. Immunization Schedules,Schedule, Immunization,Schedules, Immunization
D010567 Pertussis Vaccine A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed) Vaccine, Pertussis
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D004306 Dose-Response Relationship, Immunologic A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell. Immunologic Dose-Response Relationship,Relationship, Immunologic Dose-Response,Dose Response Relationship, Immunologic,Dose-Response Relationships, Immunologic,Immunologic Dose Response Relationship,Immunologic Dose-Response Relationships,Relationship, Immunologic Dose Response,Relationships, Immunologic Dose-Response
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000914 Antibodies, Viral Immunoglobulins produced in response to VIRAL ANTIGENS. Viral Antibodies
D012698 Serologic Tests Diagnostic procedures involving immunoglobulin reactions. Serodiagnosis,Serologic Test,Serological Tests,Test, Serologic,Tests, Serologic,Serodiagnoses,Serological Test,Test, Serological,Tests, Serological

Related Publications

O Wärngård, and L Nilsson, and C Fåhraeus, and L Gustafsson, and H O Hallander, and P Olin, and J Storsaeter
August 1999, Infection and immunity,
O Wärngård, and L Nilsson, and C Fåhraeus, and L Gustafsson, and H O Hallander, and P Olin, and J Storsaeter
April 1999, Vaccine,
O Wärngård, and L Nilsson, and C Fåhraeus, and L Gustafsson, and H O Hallander, and P Olin, and J Storsaeter
September 2004, Vaccine,
O Wärngård, and L Nilsson, and C Fåhraeus, and L Gustafsson, and H O Hallander, and P Olin, and J Storsaeter
November 2012, Clinical and vaccine immunology : CVI,
O Wärngård, and L Nilsson, and C Fåhraeus, and L Gustafsson, and H O Hallander, and P Olin, and J Storsaeter
October 1992, American journal of diseases of children (1960),
O Wärngård, and L Nilsson, and C Fåhraeus, and L Gustafsson, and H O Hallander, and P Olin, and J Storsaeter
August 1997, Fortschritte der Medizin,
O Wärngård, and L Nilsson, and C Fåhraeus, and L Gustafsson, and H O Hallander, and P Olin, and J Storsaeter
January 2012, Przeglad epidemiologiczny,
O Wärngård, and L Nilsson, and C Fåhraeus, and L Gustafsson, and H O Hallander, and P Olin, and J Storsaeter
January 2016, The new microbiologica,
O Wärngård, and L Nilsson, and C Fåhraeus, and L Gustafsson, and H O Hallander, and P Olin, and J Storsaeter
June 2002, Prescrire international,
Copied contents to your clipboard!