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Nine volunteer subjects were tested with intravenously administered cocaine hydrochloride in doses ranging from 4 to 32 mg, as well as 10 mg of dextroamphetamine sulfate. Measures of cardiovascular and subjective effects were made. Generally parallel dose-effect functions were obtained for heart rate, blood pressure, Addiction Research Center Inventory scores, Profile of Mood Scales, and subject ratings. A substantial effect on each of these variables was recorded after 8 mg of cocaine. The increase continued and peaked at approximately 16 mg after which it usually leveled off. Ten milligrams of dextroamphetamine generally had an effect comparable to 8 to 16 mg of cocaine.
M W Fischman, and
C R Schuster, and
L Resnekov, and
J F Shick, and
N A Krasnegor, and
W Fennell, and
D X Freedman
April 1991,
The Journal of pharmacology and experimental therapeutics,
M W Fischman, and
C R Schuster, and
L Resnekov, and
J F Shick, and
N A Krasnegor, and
W Fennell, and
D X Freedman
May 1992,
The Journal of pharmacology and experimental therapeutics,
M W Fischman, and
C R Schuster, and
L Resnekov, and
J F Shick, and
N A Krasnegor, and
W Fennell, and
D X Freedman
January 1991,
Psychopharmacology,
M W Fischman, and
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L Resnekov, and
J F Shick, and
N A Krasnegor, and
W Fennell, and
D X Freedman
December 1989,
Pharmacology, biochemistry, and behavior,
M W Fischman, and
C R Schuster, and
L Resnekov, and
J F Shick, and
N A Krasnegor, and
W Fennell, and
D X Freedman
January 1989,
NIDA research monograph,
M W Fischman, and
C R Schuster, and
L Resnekov, and
J F Shick, and
N A Krasnegor, and
W Fennell, and
D X Freedman
March 2006,
Drug and alcohol dependence,
M W Fischman, and
C R Schuster, and
L Resnekov, and
J F Shick, and
N A Krasnegor, and
W Fennell, and
D X Freedman
May 2004,
Pharmacology, biochemistry, and behavior,
M W Fischman, and
C R Schuster, and
L Resnekov, and
J F Shick, and
N A Krasnegor, and
W Fennell, and
D X Freedman
April 1992,
British journal of addiction,
M W Fischman, and
C R Schuster, and
L Resnekov, and
J F Shick, and
N A Krasnegor, and
W Fennell, and
D X Freedman
November 2001,
Drug and alcohol dependence,
M W Fischman, and
C R Schuster, and
L Resnekov, and
J F Shick, and
N A Krasnegor, and
W Fennell, and
D X Freedman
August 2001,
Psychopharmacology,
