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A new treatment program for advanced Hodgkin's disease employing five-drug combination chemotherapy and low dose radiation to the sites of bulk disease (nodal or parenchymal) was designed in 1969. Eighty patients have now been treated, 60 of whom have achieved a complete remission. More significantly, only 5 of the 60 completed responders have relapsed with follow-up from 1-6 years. The cumulative survival at 5 years of patients entering complete remission is 92%. For those patients not sustaining a complete remission, it is 19% at 2 years. This program has resulted in substantially lower relapse rates than previously reported by other investigators, probably because of the administration of radiotherapy in the manner described. Hopefully, a significant number of these patients may be cured of their disease.
L R Prosnitz, and
L R Farber, and
J J Fischer, and
J R Bertino, and
D B Fischer
March 1996,
Leukemia & lymphoma,
L R Prosnitz, and
L R Farber, and
J J Fischer, and
J R Bertino, and
D B Fischer
June 1997,
International journal of radiation oncology, biology, physics,
L R Prosnitz, and
L R Farber, and
J J Fischer, and
J R Bertino, and
D B Fischer
August 1998,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
L R Prosnitz, and
L R Farber, and
J J Fischer, and
J R Bertino, and
D B Fischer
January 2003,
International journal of radiation oncology, biology, physics,
L R Prosnitz, and
L R Farber, and
J J Fischer, and
J R Bertino, and
D B Fischer
March 1989,
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
L R Prosnitz, and
L R Farber, and
J J Fischer, and
J R Bertino, and
D B Fischer
September 1990,
International journal of radiation oncology, biology, physics,
L R Prosnitz, and
L R Farber, and
J J Fischer, and
J R Bertino, and
D B Fischer
October 1955,
Acta radiologica,
L R Prosnitz, and
L R Farber, and
J J Fischer, and
J R Bertino, and
D B Fischer
January 1992,
Frontiers of radiation therapy and oncology,
L R Prosnitz, and
L R Farber, and
J J Fischer, and
J R Bertino, and
D B Fischer
September 1990,
International journal of radiation oncology, biology, physics,
L R Prosnitz, and
L R Farber, and
J J Fischer, and
J R Bertino, and
D B Fischer
May 2003,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
