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To identify genes required for mammalian spermatogenesis, we screened lines of mutant mice created using a retroviral gene-trap system for male infertility. Homozygous ROSA41 male mice exhibit sterility associated with progressive testicular degeneration. Germ-cell defects are first observed at 19 days post-natal (p19). Spermatogenesis is blocked during late spermiogenesis in young adults. Gradual depletion of all stages of germ cells results in a Sertoli-cell-only phenotype by approximately six months of age. Subsequently, almost all Sertoli cells are lost from the seminiferous tubules and the Leydig cell population is reduced. Molecular analysis indicates that the gene mutated is Bclw, a death-protecting member of the Bcl2 family. The mutant allele of Bclw in ROSA41 does not produce a Bclw polypeptide. Expression of Bclw in the testis appears to be restricted to elongating spermatids and Sertoli cells. Potential roles for Bclw in testicular function are discussed.
A J Ross, and
K G Waymire, and
J E Moss, and
A F Parlow, and
M K Skinner, and
L D Russell, and
G R MacGregor
June 2022,
Cell & bioscience,
A J Ross, and
K G Waymire, and
J E Moss, and
A F Parlow, and
M K Skinner, and
L D Russell, and
G R MacGregor
October 2017,
Neuron,
A J Ross, and
K G Waymire, and
J E Moss, and
A F Parlow, and
M K Skinner, and
L D Russell, and
G R MacGregor
September 2022,
Cell & bioscience,
A J Ross, and
K G Waymire, and
J E Moss, and
A F Parlow, and
M K Skinner, and
L D Russell, and
G R MacGregor
January 1998,
The American journal of pathology,
A J Ross, and
K G Waymire, and
J E Moss, and
A F Parlow, and
M K Skinner, and
L D Russell, and
G R MacGregor
January 2001,
Development (Cambridge, England),
A J Ross, and
K G Waymire, and
J E Moss, and
A F Parlow, and
M K Skinner, and
L D Russell, and
G R MacGregor
March 2013,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
A J Ross, and
K G Waymire, and
J E Moss, and
A F Parlow, and
M K Skinner, and
L D Russell, and
G R MacGregor
January 2000,
Molecular and cellular biology,
A J Ross, and
K G Waymire, and
J E Moss, and
A F Parlow, and
M K Skinner, and
L D Russell, and
G R MacGregor
March 2016,
Investigative ophthalmology & visual science,
A J Ross, and
K G Waymire, and
J E Moss, and
A F Parlow, and
M K Skinner, and
L D Russell, and
G R MacGregor
October 2001,
Endocrinology,
A J Ross, and
K G Waymire, and
J E Moss, and
A F Parlow, and
M K Skinner, and
L D Russell, and
G R MacGregor
September 2007,
Cell cycle (Georgetown, Tex.),
