Autologous pericardial reconstruction of semilunar valves. 1998

J W Love
CardioMend LLC, Santa Barbara, California, USA.

OBJECTIVE Previous methods for reconstructing semilunar valves have been characterized by lack of precision and reproducibility and, with one exception, the use of unsuitable biomaterial. A new method combines precision with simplicity to reconstruct aortic and pulmonary valves with lightly tanned autologous tissue supported by the annulus of the native valve. Essential components include sizing based on distance between adjacent commissures, cutting a seamless, size-specific trefoil-shaped pattern of tissue with a tricuspid orifice, temporary mounting of the pattern on disposable formers, and suturing with continuous or interrupted monofilament suture to join the autologous tissue pattern with the valve annulus. METHODS The tissue pattern is cut and mounted on forming devices that enable the implanting surgeon to visualize the orientation clearly, and perform repair accurately and rapidly. One, two or three leaflets can be reconstructed. The forming and cutting devices are discarded when reconstruction is complete. Diseased valves can be reconstructed in no more time than is required for replacement with a prosthesis of any type. Advantages of the method include preservation of full effective orifice area, lack of need for any foreign body other than the sutures used for reconstruction, and the use of non-immunogenic autologous tissue known to be durable and resistant to calcific degeneration. Contraindications include heavily calcified annulus that cannot be satisfactorily debrided, bicuspid anatomy, or a significantly asymmetric annulus. RESULTS Pulmonary valve reconstructions have been performed in four juvenile sheep by this method. Three animals survived five months; there was one operative death due to non-valve related causes. CONCLUSIONS Semilunar valve reconstruction with autologous tissue can be simple, precise, and reproducible.

UI MeSH Term Description Entries
D010496 Pericardium A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers. Epicardium,Fibrous Pericardium,Parietal Pericardium,Pericardial Cavity,Pericardial Space,Serous Pericardium,Visceral Pericardium,Cavities, Pericardial,Cavity, Pericardial,Pericardial Cavities,Pericardial Spaces,Pericardium, Fibrous,Pericardium, Parietal,Pericardium, Serous,Pericardium, Visceral,Pericardiums, Fibrous,Pericardiums, Serous,Serous Pericardiums,Space, Pericardial,Spaces, Pericardial
D011664 Pulmonary Valve A valve situated at the entrance to the pulmonary trunk from the right ventricle. Pulmonary Valves,Valve, Pulmonary,Valves, Pulmonary
D006349 Heart Valve Diseases Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE). Heart Valvular Disease,Valvular Heart Diseases,Disease, Heart Valvular,Heart Disease, Valvular,Heart Valve Disease,Heart Valvular Diseases,Valve Disease, Heart,Valvular Disease, Heart,Valvular Heart Disease
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001021 Aortic Valve The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle. Aortic Valves,Valve, Aortic,Valves, Aortic
D012756 Sheep Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS. Ovis,Sheep, Dall,Dall Sheep,Ovis dalli
D014182 Transplantation, Autologous Transplantation of an individual's own tissue from one site to another site. Autografting,Autologous Transplantation,Autotransplantation,Autograftings,Autologous Transplantations,Autotransplantations,Transplantations, Autologous

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