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A prospective observational study was conducted over a 10-month period to determine the clinical and laboratory manifestations of cryptococcal meningitis in Zimbabwe, a country where antifungal agents are not widely available. Eighty-nine patients with cryptococcal meningitis (median age, 34 years; range, 11-63 years; 56 males) were identified from 406 patients for whom a clinical diagnosis of meningitis had been made. All patients tested were positive for antibody to human immunodeficiency virus. Cryptococcal meningitis was the first AIDS-defining illness in 88% of patients. Typical presentations were headache, mental impairment, and meningism (median duration, 14 days; range, 1-180 days). The median CD4+ cell count was 70/microL (range, 0-651/microL). The cumulative median survival from the time of diagnosis was 14 days (range, 0-233 days); 22% of patients survived for >30 days. Independent indicators of a good prognosis were not identified. This study provides a unique basis for the development of novel management strategies for patients with cryptococcal meningitis who reside in resource-poor countries.
R S Heyderman, and
I T Gangaidzo, and
J G Hakim, and
J Mielke, and
A Taziwa, and
P Musvaire, and
V J Robertson, and
P R Mason
April 1992,
The Journal of infectious diseases,
R S Heyderman, and
I T Gangaidzo, and
J G Hakim, and
J Mielke, and
A Taziwa, and
P Musvaire, and
V J Robertson, and
P R Mason
December 1996,
The Pediatric infectious disease journal,
R S Heyderman, and
I T Gangaidzo, and
J G Hakim, and
J Mielke, and
A Taziwa, and
P Musvaire, and
V J Robertson, and
P R Mason
June 2016,
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R S Heyderman, and
I T Gangaidzo, and
J G Hakim, and
J Mielke, and
A Taziwa, and
P Musvaire, and
V J Robertson, and
P R Mason
February 2018,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
R S Heyderman, and
I T Gangaidzo, and
J G Hakim, and
J Mielke, and
A Taziwa, and
P Musvaire, and
V J Robertson, and
P R Mason
November 2006,
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease,
R S Heyderman, and
I T Gangaidzo, and
J G Hakim, and
J Mielke, and
A Taziwa, and
P Musvaire, and
V J Robertson, and
P R Mason
July 1998,
The Journal of infectious diseases,
R S Heyderman, and
I T Gangaidzo, and
J G Hakim, and
J Mielke, and
A Taziwa, and
P Musvaire, and
V J Robertson, and
P R Mason
January 2004,
The Southeast Asian journal of tropical medicine and public health,
R S Heyderman, and
I T Gangaidzo, and
J G Hakim, and
J Mielke, and
A Taziwa, and
P Musvaire, and
V J Robertson, and
P R Mason
January 2011,
Journal of neurology,
R S Heyderman, and
I T Gangaidzo, and
J G Hakim, and
J Mielke, and
A Taziwa, and
P Musvaire, and
V J Robertson, and
P R Mason
September 2018,
The American journal of tropical medicine and hygiene,
R S Heyderman, and
I T Gangaidzo, and
J G Hakim, and
J Mielke, and
A Taziwa, and
P Musvaire, and
V J Robertson, and
P R Mason
January 2004,
The Central African journal of medicine,
