Biomaterial Database

Creatinine clearance following cimetidine for estimation of glomerular filtration rate. 1998

S Hellerstein, and M Berenbom, and U S Alon, and B A Warady

Section of Nephrology, The Children's Mercy Hospital and The University of Missouri, School of Medicine at Kansas City, 64108, USA.

Simultaneous inulin (C[in]) and creatinine clearance (C[Cr]) studies were performed on 53 pediatric renal patients using a cimetidine protocol. Since cimetidine blocks the tubular secretion of creatinine, it was hypothesized that C(Cr) measured following cimetidine would closely approximate the C(in). C(in) was compared with C(Cr) with the latter calculated from: (1) a 24-h urine collection, (2) plasma creatinine, height, and a proportionality constant, (3) the same plasma and urine specimens used for calculating C(in), and (4) from the plasma and urine specimens of the four 30-min clearance periods treated as a single 2-h clearance. The C(in) was very closely approximated by the C(Cr) calculated from the same specimens used for the C(in) and by the 2-h clearance. The cimetidine protocol, with C(Cr) derived from a 2-h urine collection obtained under supervision in the office or clinic, provides a convenient and inexpensive procedure for estimation of glomerular filtration rate in a clinical setting.

UI	MeSH Term	Description	Entries
D007444	Inulin	A starch found in the tubers and roots of many plants. Since it is hydrolyzable to FRUCTOSE, it is classified as a fructosan. It has been used in physiologic investigation for determination of the rate of glomerular function.
D007674	Kidney Diseases	Pathological processes of the KIDNEY or its component tissues.	Disease, Kidney,Diseases, Kidney,Kidney Disease
D008297	Male		Males
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D002857	Chromium	A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.
D002927	Cimetidine	A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.	Altramet,Biomet,Biomet400,Cimetidine HCl,Cimetidine Hydrochloride,Eureceptor,Histodil,N-Cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine,SK&F-92334,SKF-92334,Tagamet,HCl, Cimetidine,Hydrochloride, Cimetidine,SK&F 92334,SK&F92334,SKF 92334,SKF92334
D003404	Creatinine		Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D005260	Female		Females
D005919	Glomerular Filtration Rate	The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.	Filtration Rate, Glomerular,Filtration Rates, Glomerular,Glomerular Filtration Rates,Rate, Glomerular Filtration,Rates, Glomerular Filtration