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1. After administration of a new vasopressin analogue (DDAVP), a marked and prolonged antidiuresis occurred in 10 patients with pituitary diabetes insipidus. 2. The antidiuretic effects of single intravenous doses of 0.04--24 mug DDAVP and single intranasal doses of 5--320 mug DDAVP were investigated. Time curves of the antidiuretic responses expressed in changes of urine osmolality (Uosm) and free water clearance per 100 ml GFR (CH2O X 100/GFR) are described. 3. Maximal "peak" response was obtained after an intravenous dose of 1 mug within the first 12 hrs (Uosm was 7--800 mOsm/KgH2O). Further increase of dosage resulted only in prolongation of duration of action (up to 48 hrs) and peak ("plateau") effect (up to 24 hrs). 4. There was a linear relationship between the log dose and log osmolality of urine collected in the second 12 hours after administration of single intravenous and intranasal doses of DDAVP. 5. Comparison of the effects of 1 mug lysine-vasopressin and 1 mug DDAVP revealed only slight differences in peak effects, but extreme differences in duration of action. 6. It is concluded that in the evaluation of a synthetic vasopressin analogue the maximal antidiuretic ability and the prolongation of action have to be analysed separately.
J P Radó, and
J Marosi, and
L Szende, and
L Borbély, and
J Takó, and
J Fischer
January 1974,
The Journal of pharmacology and experimental therapeutics,
J P Radó, and
J Marosi, and
L Szende, and
L Borbély, and
J Takó, and
J Fischer
June 1976,
Journal of medicinal chemistry,
J P Radó, and
J Marosi, and
L Szende, and
L Borbély, and
J Takó, and
J Fischer
August 1985,
Revista medica de Chile,
J P Radó, and
J Marosi, and
L Szende, and
L Borbély, and
J Takó, and
J Fischer
November 1989,
Ugeskrift for laeger,
J P Radó, and
J Marosi, and
L Szende, and
L Borbély, and
J Takó, and
J Fischer
December 1984,
Analytical biochemistry,
J P Radó, and
J Marosi, and
L Szende, and
L Borbély, and
J Takó, and
J Fischer
December 2000,
British journal of haematology,
J P Radó, and
J Marosi, and
L Szende, and
L Borbély, and
J Takó, and
J Fischer
October 1980,
The Tohoku journal of experimental medicine,
J P Radó, and
J Marosi, and
L Szende, and
L Borbély, and
J Takó, and
J Fischer
November 1985,
Ugeskrift for laeger,
J P Radó, and
J Marosi, and
L Szende, and
L Borbély, and
J Takó, and
J Fischer
March 1980,
Orvosi hetilap,
J P Radó, and
J Marosi, and
L Szende, and
L Borbély, and
J Takó, and
J Fischer
June 1988,
Cellular and molecular neurobiology,
