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Plasma levels of growth hormone (GH) and prolactin (PRL) were measured in twelve acromegalic patients after acute administration of an ergoline derivative (methergoline) which has been proposed as a specific serotoninergic blocking agent. The administration of methergoline (4 mg p.o.) was followed by a significant decrease in plasma GH and PRL concentrations. The administration to the same subjects of CB 154 (2.5 mg p.o.), a known stimulator of dopaminergic receptors, led to results almost superimposable to those obtained with methergoline although the suppressive effect of CB 154 on GH and PRL levels was more sustained. Also on the ground of results obtained in these patients with the use of cyproheptadine, phentolamine, or pimozide, we have concluded that methergoline inhibition of GH and PRL release is, in acromegalic patients, most probably due to a dopaminergic mechanism of action.
P G Chiodini, and
A Liuzzi, and
E E Muller, and
L Botalla, and
G Cremascoli, and
G Oppizzi, and
G Verde, and
F Silvestrini
September 1974,
The Journal of clinical endocrinology and metabolism,
P G Chiodini, and
A Liuzzi, and
E E Muller, and
L Botalla, and
G Cremascoli, and
G Oppizzi, and
G Verde, and
F Silvestrini
March 1977,
The Journal of clinical endocrinology and metabolism,
P G Chiodini, and
A Liuzzi, and
E E Muller, and
L Botalla, and
G Cremascoli, and
G Oppizzi, and
G Verde, and
F Silvestrini
January 1976,
Clinical endocrinology,
P G Chiodini, and
A Liuzzi, and
E E Muller, and
L Botalla, and
G Cremascoli, and
G Oppizzi, and
G Verde, and
F Silvestrini
August 1977,
The Journal of clinical endocrinology and metabolism,
P G Chiodini, and
A Liuzzi, and
E E Muller, and
L Botalla, and
G Cremascoli, and
G Oppizzi, and
G Verde, and
F Silvestrini
January 1980,
Journal of endocrinological investigation,
P G Chiodini, and
A Liuzzi, and
E E Muller, and
L Botalla, and
G Cremascoli, and
G Oppizzi, and
G Verde, and
F Silvestrini
July 1983,
Clinical pharmacology and therapeutics,
P G Chiodini, and
A Liuzzi, and
E E Muller, and
L Botalla, and
G Cremascoli, and
G Oppizzi, and
G Verde, and
F Silvestrini
November 1979,
Clinical endocrinology,
P G Chiodini, and
A Liuzzi, and
E E Muller, and
L Botalla, and
G Cremascoli, and
G Oppizzi, and
G Verde, and
F Silvestrini
December 1976,
The Journal of clinical endocrinology and metabolism,
P G Chiodini, and
A Liuzzi, and
E E Muller, and
L Botalla, and
G Cremascoli, and
G Oppizzi, and
G Verde, and
F Silvestrini
September 1978,
The Journal of clinical endocrinology and metabolism,
P G Chiodini, and
A Liuzzi, and
E E Muller, and
L Botalla, and
G Cremascoli, and
G Oppizzi, and
G Verde, and
F Silvestrini
January 1975,
Endocrinologia experimentalis,
