Biomaterial Database

[Cord blood stem cell transplantation and cord blood bank]. 1998

K Ikuta

Department of Pediatrics, School of Medicine, Yokohama City University.

Human cord blood provides a rich source of hematopoietic stem cells. On the basis of the finding, umbilical cord blood has been postulated to be an alternative and efficacious source of hematopoietic stem cells for allogeneic reconstitution. Early results of cord blood stem cell transplantation (CBSCT) show that the incidence and severity of graft versus host disease has been low in HLA mismatched transplants. Cord blood banking has several advantages such as lack of donor risk, indefinite storage, speed of donor search, viral safety. More than four hundred cases of unrelated CBSCT have been performed in the world. Kanagawa cord blood bank has been established on 1995 and other some private cord blood banks have been established in Japan. Eleven cases of unrelated CBSCT have been reported in Japan. Large scaled public cord blood bank should be established in near future.

UI	MeSH Term	Description	Entries
D007564	Japan	A country in eastern Asia, island chain between the North Pacific Ocean and the Sea of Japan, east of the Korean Peninsula. The capital is Tokyo.	Bonin Islands
D001771	Blood Banks	Centers for collecting, characterizing and storing blood or plasma.	Bank, Blood,Banks, Blood,Blood Bank
D001793	Blood Preservation	The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).	Blood Preservations,Preservation, Blood,Preservations, Blood
D001800	Blood Specimen Collection	The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.	Blood Specimen Collections,Collection, Blood Specimen,Collections, Blood Specimen,Specimen Collection, Blood,Specimen Collections, Blood
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D005260	Female		Females
D005312	Fetal Blood	Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.	Cord Blood,Umbilical Cord Blood,Blood, Cord,Blood, Fetal,Blood, Umbilical Cord,Bloods, Cord,Bloods, Fetal,Bloods, Umbilical Cord,Cord Blood, Umbilical,Cord Bloods,Cord Bloods, Umbilical,Fetal Bloods,Umbilical Cord Bloods
D006648	Histocompatibility	The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.	HLA Incompatibility,Histoincompatibility,Human Leukocyte Antigen Incompatibility,Immunocompatibility,Tissue Compatibility,Compatibility, Tissue,HLA Incompatibilities,Histocompatibilities,Histoincompatibilities,Immunocompatibilities,Incompatibility, HLA,Tissue Compatibilities
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man