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The neuropoietic cytokines of the interleukin-6 family are a group of structurally and functionally related polypeptides. We studied the effect of the multifunctional neuropoietic cytokines, including oncostatin M (OSM), leukemia inhibitory factor (LIF) and interleukin-6 (IL-6), on anaplastic glioma cell lines. Growth and morphology of the glioma cell lines were affected differently. While IL-6 and LIF exerted no or only small minor morphological changes and growth retardation, OSM induced a marked change in morphology and a strong suppression of growth. OSM treated cells were characterized by enlargement and the formation of multiple, thin processes thus resembling mature cultured astrocytes. The growth inhibitory effects were dose dependent with a maximum exerted by addition of 50 ng/ml OSM. The inhibition of DNA synthesis by OSM could be abolished by antibodies blocking either the activity of OSM or the OSM-receptor component, gp130.
H Halfter, and
R Lotfi, and
R Westermann, and
P Young, and
E B Ringelstein, and
F T Stögbauer
March 2001,
Journal of neurochemistry,
H Halfter, and
R Lotfi, and
R Westermann, and
P Young, and
E B Ringelstein, and
F T Stögbauer
May 2005,
Oncology reports,
H Halfter, and
R Lotfi, and
R Westermann, and
P Young, and
E B Ringelstein, and
F T Stögbauer
January 2013,
Asian Pacific journal of cancer prevention : APJCP,
H Halfter, and
R Lotfi, and
R Westermann, and
P Young, and
E B Ringelstein, and
F T Stögbauer
January 1994,
Cytokine,
H Halfter, and
R Lotfi, and
R Westermann, and
P Young, and
E B Ringelstein, and
F T Stögbauer
June 2001,
International journal of radiation oncology, biology, physics,
H Halfter, and
R Lotfi, and
R Westermann, and
P Young, and
E B Ringelstein, and
F T Stögbauer
December 2017,
Oncotarget,
H Halfter, and
R Lotfi, and
R Westermann, and
P Young, and
E B Ringelstein, and
F T Stögbauer
May 1987,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
H Halfter, and
R Lotfi, and
R Westermann, and
P Young, and
E B Ringelstein, and
F T Stögbauer
January 1990,
Growth factors (Chur, Switzerland),
H Halfter, and
R Lotfi, and
R Westermann, and
P Young, and
E B Ringelstein, and
F T Stögbauer
May 1999,
Molecular cell biology research communications : MCBRC,
H Halfter, and
R Lotfi, and
R Westermann, and
P Young, and
E B Ringelstein, and
F T Stögbauer
November 2006,
Cancer research,
