Do infants with cystic fibrosis need a protein hydrolysate formula? A prospective, randomized, comparative study. 1998

L Ellis, and D Kalnins, and M Corey, and J Brennan, and P Pencharz, and P Durie
Research Institute and the Department of Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada.

OBJECTIVE We compared the nutritional benefits of a protein hydrolysate and a conventional infant formula in infants newly diagnosed with cystic fibrosis (CF). METHODS Twenty-three infants with CF (<6 months of age) and pancreatic insufficiency were randomized to receive a hydrolysate formula (Alimentum) or a cow's milk-based formula (Similac). Each patient was monitored at 1 month and then every 3 months for 1 year. RESULTS Eighteen patients (8 Alimentum, 10 Similac) completed the study. At entry, the age distribution and clinical characteristics of each group were comparable. Energy intake with each formula was the same at 1 and 3 months, but at 6 and 12 months the hydrolysate-fed infants had higher age-adjusted energy intake. There were no differences in fecal energy or fecal fat at entry or throughout the study. Although the hydrolysate-fed infants were slightly more malnourished at diagnosis, growth velocity and nutritional status of infants with CF in each group were the same throughout the study. CONCLUSIONS The results of this randomized study fail to support the use of a hydrolyzed formula for the routine care of infants newly diagnosed with CF.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007225 Infant Food Food processed and manufactured for the nutritional health of children in their first year of life. Food, Infant,Foods, Infant,Infant Foods
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008297 Male Males
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D011492 Protein Hydrolysates A complex mixture of OLIGOPEPTIDES, PEPTIDES, and free AMINO ACIDS that are produced by partial or extensive hydrolysis. Protein Hydrolysate,Hydrolysate, Protein,Hydrolysates, Protein
D012044 Regression Analysis Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable. Regression Diagnostics,Statistical Regression,Analysis, Regression,Analyses, Regression,Diagnostics, Regression,Regression Analyses,Regression, Statistical,Regressions, Statistical,Statistical Regressions
D002149 Energy Intake Total number of calories taken in daily whether ingested or by parenteral routes. Caloric Intake,Calorie Intake,Intake, Calorie,Intake, Energy
D003550 Cystic Fibrosis An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. Mucoviscidosis,Cystic Fibrosis of Pancreas,Fibrocystic Disease of Pancreas,Pancreatic Cystic Fibrosis,Pulmonary Cystic Fibrosis,Cystic Fibrosis, Pancreatic,Cystic Fibrosis, Pulmonary,Fibrosis, Cystic,Pancreas Fibrocystic Disease,Pancreas Fibrocystic Diseases
D005260 Female Females

Related Publications

L Ellis, and D Kalnins, and M Corey, and J Brennan, and P Pencharz, and P Durie
November 1993, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology,
L Ellis, and D Kalnins, and M Corey, and J Brennan, and P Pencharz, and P Durie
October 1987, Journal of the American Dietetic Association,
L Ellis, and D Kalnins, and M Corey, and J Brennan, and P Pencharz, and P Durie
January 2003, The Journal of international medical research,
L Ellis, and D Kalnins, and M Corey, and J Brennan, and P Pencharz, and P Durie
February 1993, Acta paediatrica (Oslo, Norway : 1992),
L Ellis, and D Kalnins, and M Corey, and J Brennan, and P Pencharz, and P Durie
October 2017, The Cochrane database of systematic reviews,
L Ellis, and D Kalnins, and M Corey, and J Brennan, and P Pencharz, and P Durie
July 2019, The Cochrane database of systematic reviews,
L Ellis, and D Kalnins, and M Corey, and J Brennan, and P Pencharz, and P Durie
January 2018, Thorax,
L Ellis, and D Kalnins, and M Corey, and J Brennan, and P Pencharz, and P Durie
October 1991, Journal of pediatric gastroenterology and nutrition,
L Ellis, and D Kalnins, and M Corey, and J Brennan, and P Pencharz, and P Durie
November 1990, Journal of pediatric gastroenterology and nutrition,
L Ellis, and D Kalnins, and M Corey, and J Brennan, and P Pencharz, and P Durie
July 1994, Pediatric pulmonology,
Copied contents to your clipboard!