BIOMAT Database Logo BIOMAT Database Logo

Synthesis of 5H-dipyrido[1,2-a:2',3'-d]pyrimidin-5-ones as potential antiallergy agents. 1997

A Rykowski, and W Pucko
Institute of Chemistry, Agricultural and Pedagogical University, Siedlce, Poland.

A novel synthesis of 5H-dipyrido[1,2-a:2',3'-d]pyrimidin-5-ones is described. The method is based on Ullmann condensation of 2-chloronicotinic acid and its 5-bromo analoguewith 2-aminopyridine 1-oxides, followed by intramolecular cyclization of the resulting 3-carboxy-2,2'-bipyridylamine 1'-oxides with phosphorous.

UI MeSH Term Description Entries
D011725 Pyridines Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
D011744 Pyrimidinones Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones (or 4-hydroxypyrimidines) with the general formula C4H4N2O. Pyrimidinone,Pyrimidone,Pyrimidones
D018926 Anti-Allergic Agents Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) Anti-Allergic,Anti-Allergic Agent,Anti-Allergy Drug,Antiallergic,Antiallergic Agent,Antiallergic Drug,Anti-Allergics,Anti-Allergy Drugs,Antiallergic Agents,Antiallergic Drugs,Antiallergics,Antiallergy Agents,Agent, Anti-Allergic,Agent, Antiallergic,Agents, Anti-Allergic,Agents, Antiallergic,Agents, Antiallergy,Anti Allergic,Anti Allergic Agent,Anti Allergic Agents,Anti Allergics,Anti Allergy Drug,Anti Allergy Drugs,Drug, Anti-Allergy,Drug, Antiallergic,Drugs, Anti-Allergy,Drugs, Antiallergic

Related Publications

A Rykowski, and W Pucko
Synthesis of pyrido[2,1-b]quinazolin-11-ones and dipyrido[1,2-a:2',3'-d]pyrimidin-5-ones by Pd/DIBPP-catalyzed dearomatizing carbonylation.
March 2015, Organic letters,
A Rykowski, and W Pucko
Antiallergy agents. 2. 2-Phenyl-5-(1H-tetrazol-5-yl)pyrimidin-4(3H)-ones.
October 1982, Journal of medicinal chemistry,
A Rykowski, and W Pucko
Guanosine analogues. Synthesis of nucleosides of certain 3-substituted 6-aminopyrazolo[3,4-d]pyrimidin-4(5H)-ones as potential immunotherapeutic agents.
August 1990, Journal of medicinal chemistry,
A Rykowski, and W Pucko
Synthesis of pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-ones as potential antimicrobial agents.
May 2013, Archives of pharmacal research,
A Rykowski, and W Pucko
Synthesis of pyrido[1,2-a]pyrimidin-4-ones. Potential antihypertensive agents. III.
December 1986, Il Farmaco; edizione scientifica,
A Rykowski, and W Pucko
Synthesis of pyrazolo[3,4-d]pyrimidin-4(5H)-ones tethered to 1,2,3-triazoles and their evaluation as potential anticancer agents.
August 2018, European journal of medicinal chemistry,
A Rykowski, and W Pucko
Evaluation of 5H-Thiazolo[3,2-α]pyrimidin-5-ones as Potential GluN2A PET Tracers.
December 2020, ChemMedChem,
A Rykowski, and W Pucko
Synthesis of some 4H-pyrido[1,2-a]pyrimidin-4-ones investigated as antimicrobial agents.
January 1995, Farmaco (Societa chimica italiana : 1989),
A Rykowski, and W Pucko
Synthesis and evaluation of 5-arylated 2(5H)-furanones and 2-arylated pyridazin-3(2H)-ones as anti-cancer agents.
September 2003, The Journal of pharmacy and pharmacology,
A Rykowski, and W Pucko
InCl3-catalysed synthesis of 2-aryl quinazolin-4(3H)-ones and 5-aryl pyrazolo[4,3-d]pyrimidin-7(6H)-ones and their evaluation as potential anticancer agents.
August 2012, Bioorganic & medicinal chemistry letters,
Copied contents to your clipboard!