-transparent.png){kind=logo}
The effects of Hange-shashin-to (TJ-14) on cholera toxin-induced intestinal fluid secretion were studied to elucidate the mechanism by which this kampo medicine manifests antidiarrheal effects. TJ-14 suppressed the intestinal fluid secretion induced by cholera toxin (1 microg/rat) in a dose-dependent manner at doses between 125 and 1000 mg/kg. It also inhibited the luminal prostaglandin E2 (PGE2) level. On the other hand, serotonin (5-HT) release was not affected by TJ-14. Subcutaneous injection of indomethacin at 10 mg/kg or ondansetron at 100 microg/kg significantly suppressed intestinal secretion. The luminal PGE2 level was also inhibited by indomethacin (10 mg/kg, s.c.). TJ-14, even at 10(-4) g/ml, had little effect on the phasic contraction of isolated guinea pig ileum induced by 5-HT (2 x 10(-6) g/ml), while ondansetron suppressed the phasic contraction caused by 5-HT. These results indicate that TJ-14 is useful in suppressing cholera toxin-stimulated intestinal fluid secretion, and that this effect is partially due to its suppressive action on the PGE2 level.
Y Kase, and
K Saitoh, and
M Yuzurihara, and
A Ishige, and
Y Komatsu
July 1979,
Gastroenterology,
Y Kase, and
K Saitoh, and
M Yuzurihara, and
A Ishige, and
Y Komatsu
August 1978,
Infection and immunity,
Y Kase, and
K Saitoh, and
M Yuzurihara, and
A Ishige, and
Y Komatsu
October 1996,
Biological & pharmaceutical bulletin,
Y Kase, and
K Saitoh, and
M Yuzurihara, and
A Ishige, and
Y Komatsu
September 1997,
Biological & pharmaceutical bulletin,
Y Kase, and
K Saitoh, and
M Yuzurihara, and
A Ishige, and
Y Komatsu
November 1993,
Gastroenterology,
Y Kase, and
K Saitoh, and
M Yuzurihara, and
A Ishige, and
Y Komatsu
April 2001,
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine,
Y Kase, and
K Saitoh, and
M Yuzurihara, and
A Ishige, and
Y Komatsu
January 1998,
Methods and findings in experimental and clinical pharmacology,
Y Kase, and
K Saitoh, and
M Yuzurihara, and
A Ishige, and
Y Komatsu
August 1993,
Acta physiologica Scandinavica,
Y Kase, and
K Saitoh, and
M Yuzurihara, and
A Ishige, and
Y Komatsu
December 1993,
The American journal of physiology,
Y Kase, and
K Saitoh, and
M Yuzurihara, and
A Ishige, and
Y Komatsu
November 1979,
Experientia,
