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An 8-year-old boy with goiter and bilateral nerve deafness had a 46% discharge of radioiodine after thiocyanate administration. He was clinically euthyroid. Although the serum total T4 was low (2.4 mug/100 ml) and TSH was significantly high (181 muU/ml), the serum total T3 was normal (152 ng/100ml). It was considered that the increased release of TSH by the feedback mechanism in response to the low T4 resulted in a quite normal level of serum T3. The thyroid gland demonstrated a low stable iodine content, an increase in MIT/DIT ration and a decrease in iodothyronine. The thyroglobulin behaved normally in Sephadex G-200 chromatography and immunoreaction. Thyroid tissue exhibited increased peroxidase activity as measured by I3 formation. Increased peroxidase activity may be related to the observed increase in serum level of TSH.
M Yamamoto, and
S Saito, and
T Sakurada, and
K Yoshida, and
K Yoshinaga
March 1973,
The Journal of clinical endocrinology and metabolism,
M Yamamoto, and
S Saito, and
T Sakurada, and
K Yoshida, and
K Yoshinaga
January 1973,
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M Yamamoto, and
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K Yoshinaga
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M Yamamoto, and
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M Yamamoto, and
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M Yamamoto, and
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K Yoshida, and
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M Yamamoto, and
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March 1993,
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M Yamamoto, and
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February 1986,
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M Yamamoto, and
S Saito, and
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M Yamamoto, and
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Das Deutsche Gesundheitswesen,
