[Radiation pneumonitis and radiation fibrosis following systemic irradiation of thoracic lymph nodes in Hodgkin's disease]. 1976

W Castrup, and M Wannenmacher, and M Blömer

146 of 226 patients suffering from Hodgkin's disease were submitted to a high voltage therapy in the chest using the method of single fields. In order to be in a position to judge the appearance and the development of a modification of the pulmonary parenchyma induced by radiations, the authors evaluated the data of 69 patients who could be checked up in relatively small intervals during at least one year after the radiotherapy. Dilatations of interpleural and hilar lymphomas or pulmonary infiltrates have to be considered as one of the most important causes of atypical pneumonia and fibrosis induced by radiation. 12 patients out of 35 (i.e. 35,3%) with intrathoracic lymphomatosis granulomatosa presented atypical pneumonias which mostly were not very serious, and four patients (i.e. 11,8%) had fibroses. If the mediastine was irradiated systematically for the purpose of prophylaxis, no pulmonary reaction was observed that could be demonstrated by means of X-rays.

UI MeSH Term Description Entries
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008198 Lymph Nodes They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system. Lymph Node,Node, Lymph,Nodes, Lymph
D008297 Male Males
D008482 Mediastinum A membrane in the midline of the THORAX of mammals. It separates the lungs between the STERNUM in front and the VERTEBRAL COLUMN behind. It also surrounds the HEART, TRACHEA, ESOPHAGUS, THYMUS, and LYMPH NODES.
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011658 Pulmonary Fibrosis A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death. Alveolitis, Fibrosing,Idiopathic Diffuse Interstitial Pulmonary Fibrosis,Fibroses, Pulmonary,Fibrosis, Pulmonary,Pulmonary Fibroses,Alveolitides, Fibrosing,Fibrosing Alveolitides,Fibrosing Alveolitis
D011832 Radiation Injuries Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES. Radiation Sickness,Radiation Syndrome,Injuries, Radiation,Injury, Radiation,Radiation Injury,Radiation Sicknesses,Radiation Syndromes,Sickness, Radiation,Sicknesses, Radiation,Syndrome, Radiation,Syndromes, Radiation
D011867 Radioisotope Teletherapy A type of high-energy radiotherapy using a beam of gamma-radiation produced by a radioisotope source encapsulated within a teletherapy unit. Teleradioisotope Therapy,Teletherapy, Radioisotope,Therapy, Teleradioisotope
D011879 Radiotherapy Dosage The total amount of radiation absorbed by tissues as a result of radiotherapy. Dosage, Radiotherapy,Dosages, Radiotherapy,Radiotherapy Dosages
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children

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