BIOMAT Database Logo BIOMAT Database Logo

Specific group II metabotropic glutamate receptor activation inhibits the development of kindled epilepsy in rats. 1998

P J Attwell, and A Koumentaki, and A S Abdul-Ghani, and M J Croucher, and H F Bradford
Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK.

The effects of intracerebral administration of the group II metabotropic glutamate receptor agonist, 2R,4R-APDC, were tested on both the development of amygdaloid kindling and on fully developed stage 5 amygdala kindled seizures. The development of amygdaloid kindling was significantly retarded in 2R,4R-APDC (10 nmol in 0.5 microl) treated animals compared to control animals over a period of 8 days. At a low dose, 2R,4R-APDC (0.1 nmol) caused a 42.5+/-26.6% increase of the generalised seizure threshold in fully kindled animals. As higher doses were administered, however, the changes in generalised seizure threshold were less marked, and even a small decrease in the threshold was seen (-19.6+/-5.36% at 10 nmol). The agonist 2R,4R-APDC inhibited depolarization-induced release of [3H]d-aspartate from cortical synaptosomes with an IC50 value of 0. 29 microM. This effect was maximal at 1 microM, and decreased with dose thereafter. These findings suggest that the selective activation of the group II metabotropic glutamate receptors by agonists such as 2R,4R-APDC may be of therapeutic potential in the treatment of seizure disorders.

UI MeSH Term Description Entries
D007696 Kindling, Neurologic The repeated weak excitation of brain structures, that progressively increases sensitivity to the same stimulation. Over time, this can lower the threshold required to trigger seizures. Kindlings, Neurologic,Neurologic Kindling,Neurologic Kindlings
D008297 Male Males
D009004 Monosaccharide Transport Proteins A large group of membrane transport proteins that shuttle MONOSACCHARIDES across CELL MEMBRANES. Hexose Transport Proteins,Band 4.5 Preactin,Erythrocyte Band 4.5 Protein,Glucose Transport-Inducing Protein,Hexose Transporter,4.5 Preactin, Band,Glucose Transport Inducing Protein,Preactin, Band 4.5,Proteins, Monosaccharide Transport,Transport Proteins, Hexose,Transport Proteins, Monosaccharide,Transport-Inducing Protein, Glucose
D011392 Proline A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons. L-Proline,L Proline
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004827 Epilepsy A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313) Aura,Awakening Epilepsy,Seizure Disorder,Epilepsy, Cryptogenic,Auras,Cryptogenic Epilepsies,Cryptogenic Epilepsy,Epilepsies,Epilepsies, Cryptogenic,Epilepsy, Awakening,Seizure Disorders
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000927 Anticonvulsants Drugs used to prevent SEIZURES or reduce their severity. Anticonvulsant,Anticonvulsant Drug,Anticonvulsive Agent,Anticonvulsive Drug,Antiepileptic,Antiepileptic Agent,Antiepileptic Agents,Antiepileptic Drug,Anticonvulsant Drugs,Anticonvulsive Agents,Anticonvulsive Drugs,Antiepileptic Drugs,Antiepileptics,Agent, Anticonvulsive,Agent, Antiepileptic,Agents, Anticonvulsive,Agents, Antiepileptic,Drug, Anticonvulsant,Drug, Anticonvulsive,Drug, Antiepileptic,Drugs, Anticonvulsant,Drugs, Anticonvulsive,Drugs, Antiepileptic
D013574 Synaptosomes Pinched-off nerve endings and their contents of vesicles and cytoplasm together with the attached subsynaptic area of the membrane of the post-synaptic cell. They are largely artificial structures produced by fractionation after selective centrifugation of nervous tissue homogenates. Synaptosome

Related Publications

P J Attwell, and A Koumentaki, and A S Abdul-Ghani, and M J Croucher, and H F Bradford
Activation of group II metabotropic glutamate receptors inhibits glutamate release from salamander retinal photoreceptors.
January 2002, Visual neuroscience,
P J Attwell, and A Koumentaki, and A S Abdul-Ghani, and M J Croucher, and H F Bradford
Anticonvulsant action of metabotropic glutamate receptor agonists in kindled amygdala of rats.
February 1996, Neuroscience letters,
P J Attwell, and A Koumentaki, and A S Abdul-Ghani, and M J Croucher, and H F Bradford
The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats.
June 2006, Psychopharmacology,
P J Attwell, and A Koumentaki, and A S Abdul-Ghani, and M J Croucher, and H F Bradford
Glutamate induces apoptosis in anterior pituitary cells through group II metabotropic glutamate receptor activation.
October 2004, Endocrinology,
P J Attwell, and A Koumentaki, and A S Abdul-Ghani, and M J Croucher, and H F Bradford
Group II metabotropic glutamate receptor activation attenuates peripheral sensitization in inflammatory states.
June 2008, Neuroscience,
P J Attwell, and A Koumentaki, and A S Abdul-Ghani, and M J Croucher, and H F Bradford
Endogenous activation of group-II metabotropic glutamate receptors inhibits the hypothalamic-pituitary-adrenocortical axis.
April 2003, Neuropharmacology,
P J Attwell, and A Koumentaki, and A S Abdul-Ghani, and M J Croucher, and H F Bradford
Group II metabotropic glutamate receptor activation is required for normal hippocampal mossy fibre development in the rat.
February 2002, The Journal of physiology,
P J Attwell, and A Koumentaki, and A S Abdul-Ghani, and M J Croucher, and H F Bradford
Group II metabotropic glutamate receptor activation on peripheral nociceptors modulates TRPV1 function.
January 2009, Brain research,
P J Attwell, and A Koumentaki, and A S Abdul-Ghani, and M J Croucher, and H F Bradford
Metabotropic glutamate group II receptor activation in the ventrolateral dorsal striatum suppresses incentive motivation for cocaine in rats.
June 2023, Psychopharmacology,
P J Attwell, and A Koumentaki, and A S Abdul-Ghani, and M J Croucher, and H F Bradford
Altered expression of group I metabotropic glutamate receptors in the hippocampus of amygdala-kindled rats.
December 1996, Brain research. Molecular brain research,
Copied contents to your clipboard!