-transparent.png){kind=logo}
Employing subtype-specific antisera, we measured the relative immunoreactivity of five muscarinic acetylcholine receptor (mAChR) subtype proteins (m1-m5) in the human iris. The most intensive FITC immunofluorescence was detected by the anti-m3 antibody, followed by anti-m1 and -m5 antisera, in the iris sphincter muscle cells. Only very weak fluorescence was obtained by anti-m2 and -m4 antibodies. In dilator muscle cells, weak but not consistent immunoreactivity was found by anti-m1 and -m5 antibodies. The results suggest that the m3 muscarinic receptor is the predominant subtype in sphincter muscle cells of the human iris.
Related Publications
N Ishizaka, and
M Noda, and
S Yokoyama, and
K Kawasaki, and
M Yamamoto, and
H Higashida
October 2007,
Yi chuan = Hereditas,
N Ishizaka, and
M Noda, and
S Yokoyama, and
K Kawasaki, and
M Yamamoto, and
H Higashida
June 1997,
Investigative ophthalmology & visual science,
N Ishizaka, and
M Noda, and
S Yokoyama, and
K Kawasaki, and
M Yamamoto, and
H Higashida
September 2006,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
N Ishizaka, and
M Noda, and
S Yokoyama, and
K Kawasaki, and
M Yamamoto, and
H Higashida
April 1994,
Trends in pharmacological sciences,
N Ishizaka, and
M Noda, and
S Yokoyama, and
K Kawasaki, and
M Yamamoto, and
H Higashida
January 1987,
Nature,
N Ishizaka, and
M Noda, and
S Yokoyama, and
K Kawasaki, and
M Yamamoto, and
H Higashida
December 1989,
Trends in pharmacological sciences,
N Ishizaka, and
M Noda, and
S Yokoyama, and
K Kawasaki, and
M Yamamoto, and
H Higashida
March 2006,
Molecular and cellular endocrinology,
N Ishizaka, and
M Noda, and
S Yokoyama, and
K Kawasaki, and
M Yamamoto, and
H Higashida
September 1998,
The Journal of investigative dermatology,
N Ishizaka, and
M Noda, and
S Yokoyama, and
K Kawasaki, and
M Yamamoto, and
H Higashida
January 1993,
Progress in brain research,
N Ishizaka, and
M Noda, and
S Yokoyama, and
K Kawasaki, and
M Yamamoto, and
H Higashida
December 1989,
Trends in pharmacological sciences,
