-transparent.png){kind=logo}
Melatonin receptors in the human fetal kidney were identified and characterized by quantitative in vitro autoradiography using the melatonin agonist, 2-[125I]iodomelatonin. Specific binding was localized to cells in the nephrogenic region at the outer perimeter of the developing kidney and was time-dependent, saturable and inhibited in the presence of guanosine 5'-0-(3-thiotriphosphate) indicative of a G protein-coupled receptor. Expression of the Mel1a and Mel1b melatonin receptors in human fetal kidney was determined using RT-PCR. In situ hybridization confirmed the localization of the Mel1a mRNA transcripts. A role for melatonin in development of the human fetal kidney is postulated.
J E Drew, and
L M Williams, and
L T Hannah, and
P Barrett, and
D R Abramovich
February 1996,
Endocrine research,
J E Drew, and
L M Williams, and
L T Hannah, and
P Barrett, and
D R Abramovich
January 1999,
Advances in experimental medicine and biology,
J E Drew, and
L M Williams, and
L T Hannah, and
P Barrett, and
D R Abramovich
January 2022,
Methods in molecular biology (Clifton, N.J.),
J E Drew, and
L M Williams, and
L T Hannah, and
P Barrett, and
D R Abramovich
January 1994,
Biological signals,
J E Drew, and
L M Williams, and
L T Hannah, and
P Barrett, and
D R Abramovich
June 1987,
Proceedings of the National Academy of Sciences of the United States of America,
J E Drew, and
L M Williams, and
L T Hannah, and
P Barrett, and
D R Abramovich
January 1994,
Biological signals,
J E Drew, and
L M Williams, and
L T Hannah, and
P Barrett, and
D R Abramovich
January 1994,
Biological signals,
J E Drew, and
L M Williams, and
L T Hannah, and
P Barrett, and
D R Abramovich
March 2002,
Journal of pineal research,
J E Drew, and
L M Williams, and
L T Hannah, and
P Barrett, and
D R Abramovich
May 1999,
Nature neuroscience,
J E Drew, and
L M Williams, and
L T Hannah, and
P Barrett, and
D R Abramovich
January 1994,
Biological signals,
