BIOMAT Database Logo BIOMAT Database Logo

Treatment of digitalis intoxication by charcoal hemoperfusion (CHP). 1976

A Carvallo, and B Ramirez, and H Honig, and J Knepshield, and G E Schreiner, and M C Gelfand

In the present communication, we demonstrate the removal of digoxin both in vitro and in vivo from digoxin intoxicated dogs by use of hemoperfusion over activated charcoal. In vitro drug removal was 33 ml/min at mean blood flow rates of 160 ml/min. By 30 mins of in vitro perfusion 51% of drug was removed from the reservoir and by 2 1/2 hrs 83%. In vivo clearance in dogs was 55 ml/min at blood flow rates of 150 ml/min. In view of the poor success that has been encountered in the treatment of digoxin intoxication with other modalities, charcoal hemoperfusion may represent an effective method of rapid digoxin removal from blood.

UI MeSH Term Description Entries
D010477 Perfusion Treatment process involving the injection of fluid into an organ or tissue. Perfusions
D001769 Blood The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.
D002606 Charcoal An amorphous form of carbon prepared from the incomplete combustion of animal or vegetable matter, e.g., wood. The activated form of charcoal is used in the treatment of poisoning. (Grant & Hackh's Chemical Dictionary, 5th ed) Activated Charcoal,Actidose,Actidose-Aqua,Adsorba,Carbomix,Charbon,CharcoAid,CharcoCaps,Charcodote,Formocarbine,Insta-Char,Kohle-Compretten,Kohle-Hevert,Kohle-Pulvis,Kohle-Tabletten Boxo-Pharm,Liqui-Char,Norit,Ultracarbon,Charcoal, Activated
D004071 Digitalis Glycosides Glycosides from plants of the genus DIGITALIS. Some of these are useful as cardiotonic and anti-arrhythmia agents. Included also are semi-synthetic derivatives of the naturally occurring glycosides. The term has sometimes been used more broadly to include all CARDIAC GLYCOSIDES, but here is restricted to those related to Digitalis. Glycosides, Digitalis
D004074 Digitoxin A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) Coramedan,Digimed,Digimerck,Digitaline Nativelle,Digitoxin AWD,Digitoxin Bürger,Digitoxin Didier,Digitoxin-Philo,Digophton,AWD, Digitoxin,Bürger, Digitoxin,Didier, Digitoxin,Digitoxin Philo,Nativelle, Digitaline
D004077 Digoxin A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666) Digacin,Digitek,Digoregen,Digoxina Boehringer,Digoxine Nativelle,Dilanacin,Hemigoxine Nativelle,Lanacordin,Lanicor,Lanoxicaps,Lanoxin,Lanoxin-PG,Lenoxin,Mapluxin,Boehringer, Digoxina,Lanoxin PG,Nativelle, Digoxine,Nativelle, Hemigoxine
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

A Carvallo, and B Ramirez, and H Honig, and J Knepshield, and G E Schreiner, and M C Gelfand
[Treatment of patients with acute digitalis poisoning by charcoal hemoperfusion].
January 1987, Vutreshni bolesti,
A Carvallo, and B Ramirez, and H Honig, and J Knepshield, and G E Schreiner, and M C Gelfand
Hemoperfusion in digitalis intoxication: a comparative study of coated versus uncoated charcoal.
January 1977, Transactions - American Society for Artificial Internal Organs,
A Carvallo, and B Ramirez, and H Honig, and J Knepshield, and G E Schreiner, and M C Gelfand
Charcoal hemoperfusion in the treatment of levothyroxine intoxication.
February 2010, Thyroid : official journal of the American Thyroid Association,
A Carvallo, and B Ramirez, and H Honig, and J Knepshield, and G E Schreiner, and M C Gelfand
Charcoal hemoperfusion for phenytoin intoxication.
February 2012, Indian pediatrics,
A Carvallo, and B Ramirez, and H Honig, and J Knepshield, and G E Schreiner, and M C Gelfand
Successful treatment of acute dapsone intoxication using charcoal hemoperfusion.
October 1983, Australian and New Zealand journal of medicine,
A Carvallo, and B Ramirez, and H Honig, and J Knepshield, and G E Schreiner, and M C Gelfand
Management of chloramphenicol intoxication in infancy by charcoal hemoperfusion.
September 1983, The Journal of pediatrics,
A Carvallo, and B Ramirez, and H Honig, and J Knepshield, and G E Schreiner, and M C Gelfand
[Activated charcoal hemoperfusion in the treatment of severe hypnotic intoxication].
May 1983, Zhonghua yi xue za zhi,
A Carvallo, and B Ramirez, and H Honig, and J Knepshield, and G E Schreiner, and M C Gelfand
[Hemoperfusion for therapy of severe digitalis intoxication?].
April 1980, Deutsche medizinische Wochenschrift (1946),
A Carvallo, and B Ramirez, and H Honig, and J Knepshield, and G E Schreiner, and M C Gelfand
Management of theophylline intoxication with charcoal-column hemoperfusion.
January 1979, The New England journal of medicine,
A Carvallo, and B Ramirez, and H Honig, and J Knepshield, and G E Schreiner, and M C Gelfand
Theophylline intoxication: clinical features and pharmacokinetics during treatment with charcoal hemoperfusion.
September 1996, Israel journal of medical sciences,
Copied contents to your clipboard!