BIOMAT Database Logo BIOMAT Database Logo

The effect of drug lipophilicity on P-glycoprotein-mediated colchicine efflux at the blood-brain barrier. 1998

E U Khan, and A Reichel, and D J Begley, and S J Roffey, and S G Jezequel, and N J Abbott
King's College, London, UK.

UI MeSH Term Description Entries
D008055 Lipids A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed) Lipid
D001812 Blood-Brain Barrier Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue. Brain-Blood Barrier,Hemato-Encephalic Barrier,Barrier, Blood-Brain,Barrier, Brain-Blood,Barrier, Hemato-Encephalic,Barriers, Blood-Brain,Barriers, Brain-Blood,Barriers, Hemato-Encephalic,Blood Brain Barrier,Blood-Brain Barriers,Brain Blood Barrier,Brain-Blood Barriers,Hemato Encephalic Barrier,Hemato-Encephalic Barriers
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D003078 Colchicine A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE). Colchicine, (+-)-Isomer,Colchicine, (R)-Isomer
D004176 Dipyridamole A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) Antistenocardin,Apo-Dipyridamole,Cerebrovase,Cléridium,Curantil,Curantyl,Dipyramidole,Kurantil,Miosen,Novo-Dipiradol,Persantin,Persantine,Apo Dipyridamole,Novo Dipiradol
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012995 Solubility The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Solubilities
D014700 Verapamil A calcium channel blocker that is a class IV anti-arrhythmia agent. Iproveratril,Calan,Cordilox,Dexverapamil,Falicard,Finoptin,Isoptin,Isoptine,Izoptin,Lekoptin,Verapamil Hydrochloride,Hydrochloride, Verapamil
D015215 Zidovudine A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. AZT (Antiviral),Azidothymidine,3'-Azido-2',3'-Dideoxythymidine,3'-Azido-3'-deoxythymidine,AZT Antiviral,AZT, Antiviral,BW A509U,BWA-509U,Retrovir,3' Azido 2',3' Dideoxythymidine,3' Azido 3' deoxythymidine,Antiviral AZT,BWA 509U,BWA509U
D016572 Cyclosporine A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed). Cyclosporin A,Ciclosporin,CsA-Neoral,CyA-NOF,Cyclosporin,Cyclosporine A,Neoral,OL 27-400,Sandimmun,Sandimmun Neoral,Sandimmune,CsA Neoral,CsANeoral,CyA NOF,OL 27 400,OL 27400

Related Publications

E U Khan, and A Reichel, and D J Begley, and S J Roffey, and S G Jezequel, and N J Abbott
P-glycoprotein-mediated efflux transport of anticancer drugs at the blood-brain barrier.
October 1998, Therapeutic drug monitoring,
E U Khan, and A Reichel, and D J Begley, and S J Roffey, and S G Jezequel, and N J Abbott
Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier.
January 2013, Journal of labelled compounds & radiopharmaceuticals,
E U Khan, and A Reichel, and D J Begley, and S J Roffey, and S G Jezequel, and N J Abbott
A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier.
May 2016, The Journal of clinical investigation,
E U Khan, and A Reichel, and D J Begley, and S J Roffey, and S G Jezequel, and N J Abbott
The role of the efflux transporter, P-glycoprotein, at the blood-brain barrier in drug discovery.
February 2023, Biopharmaceutics & drug disposition,
E U Khan, and A Reichel, and D J Begley, and S J Roffey, and S G Jezequel, and N J Abbott
Oseltamivir (Tamiflu) efflux transport at the blood-brain barrier via P-glycoprotein.
January 2008, Drug metabolism and disposition: the biological fate of chemicals,
E U Khan, and A Reichel, and D J Begley, and S J Roffey, and S G Jezequel, and N J Abbott
Blood-brain barrier transport of naloxone does not involve P-glycoprotein-mediated efflux.
January 2010, Journal of pharmaceutical sciences,
E U Khan, and A Reichel, and D J Begley, and S J Roffey, and S G Jezequel, and N J Abbott
P-glycoprotein-mediated efflux of phenobarbital at the blood-brain barrier evidence from transport experiments in vitro.
January 2008, Epilepsy research,
E U Khan, and A Reichel, and D J Begley, and S J Roffey, and S G Jezequel, and N J Abbott
Retrospective analysis of P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier in humans.
April 2013, Drug metabolism and disposition: the biological fate of chemicals,
E U Khan, and A Reichel, and D J Begley, and S J Roffey, and S G Jezequel, and N J Abbott
High brain distribution of a new central nervous system drug candidate despite its P-glycoprotein-mediated efflux at the mouse blood-brain barrier.
May 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences,
E U Khan, and A Reichel, and D J Begley, and S J Roffey, and S G Jezequel, and N J Abbott
Modeling Substrate Entry into the P-Glycoprotein Efflux Pump at the Blood-Brain Barrier.
December 2023, Journal of medicinal chemistry,
Copied contents to your clipboard!