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The purpose of this experiment was to investigate the regulation of drug intake in rats (n = 20) self-administering heroin or cocaine during daily 5-hr sessions. Operant chambers were equipped with 2 levers and associated stimulus lights. A response on the lever with stimuli signaling an increase in dose size increased the infusion duration by 3 s, and a response on the lever with stimuli signaling a decrease in dose size decreased the infusion duration by 3 s. Results showed that daily and hourly drug intake for cocaine and heroin groups were relatively constant. Significant correlation coefficients were obtained for heroin and cocaine groups for the relationship between interdose interval (IDI) and infusion duration (dose size). These findings indicate that subjects regulated their drug intake by adjusting IDI throughout drug self-administration sessions.
W J Lynch, and
L P LaBounty, and
M E Carroll
July 2005,
Psychopharmacology,
W J Lynch, and
L P LaBounty, and
M E Carroll
February 1989,
Pharmacology, biochemistry, and behavior,
W J Lynch, and
L P LaBounty, and
M E Carroll
January 1988,
Neuropeptides,
W J Lynch, and
L P LaBounty, and
M E Carroll
April 2006,
Psychopharmacology,
W J Lynch, and
L P LaBounty, and
M E Carroll
May 1999,
Psychopharmacology,
W J Lynch, and
L P LaBounty, and
M E Carroll
January 2016,
Neuroscience letters,
W J Lynch, and
L P LaBounty, and
M E Carroll
April 2016,
Psychopharmacology,
W J Lynch, and
L P LaBounty, and
M E Carroll
April 2007,
The European journal of neuroscience,
W J Lynch, and
L P LaBounty, and
M E Carroll
June 1998,
Pharmacology, biochemistry, and behavior,
W J Lynch, and
L P LaBounty, and
M E Carroll
June 1993,
Drug and alcohol dependence,
