BIOMAT Database Logo BIOMAT Database Logo

Heterogeneous fatty acid uptake early after reperfusion in rat hearts. 1998

Y Yamane, and N Ishide, and Y Kagaya, and D Takeyama, and N Shiba, and M Chida, and T Nozaki, and T Takahashi, and T Ido, and K Shirato
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.

We determined whether spatial distributions of substrate uptake are heterogeneous within the area at risk during reperfusion. Quantitative autoradiography with imaging plates and two long-lived radioisotopes was applied to 15 open-chest, anesthetized rats subjected to 30 min of coronary artery ligation and 30 min of reperfusion. Regions showing increased beta-methyl-[1-14C]heptadecanoic acid ([14C]BMHDA) uptake (166 +/- 17% of that in the nonischemic area) appeared at the lateral borders and subepicardial layer within the area at risk, and 2-deoxy-D-[1-3H]glucose ([3H]DG) uptake was 103 +/- 24% in these regions. Regions with decreased [14C]BMHDA uptake (28 +/- 11%) occupied the midmyocardial layer except at the lateral borders within the area at risk, and [3H]DG uptake was 62 +/- 18% in these regions. The percentage interregional coefficients of variation (index of heterogeneity) in [14C]BMHDA uptake, [3H]DG uptake, and blood flow were higher in the area at risk than in the nonischemic area (76 +/- 23 vs. 21 +/- 7%, 39 +/- 10 vs. 21 +/- 7%, and 49 +/- 19 vs. 14 +/- 4%, respectively). Heterogeneous distributions of substrate uptake may explain the conflicting results concerning substrate metabolism during reperfusion.

UI MeSH Term Description Entries
D008297 Male Males
D003326 Coronary Circulation The circulation of blood through the CORONARY VESSELS of the HEART. Circulation, Coronary
D005227 Fatty Acids Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed) Aliphatic Acid,Esterified Fatty Acid,Fatty Acid,Fatty Acids, Esterified,Fatty Acids, Saturated,Saturated Fatty Acid,Aliphatic Acids,Acid, Aliphatic,Acid, Esterified Fatty,Acid, Saturated Fatty,Esterified Fatty Acids,Fatty Acid, Esterified,Fatty Acid, Saturated,Saturated Fatty Acids
D005947 Glucose A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001692 Biological Transport The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments. Transport, Biological,Biologic Transport,Transport, Biologic
D015428 Myocardial Reperfusion Injury Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm. Reperfusion Injury, Myocardial,Injury, Myocardial Reperfusion,Myocardial Ischemic Reperfusion Injury,Injuries, Myocardial Reperfusion,Myocardial Reperfusion Injuries,Reperfusion Injuries, Myocardial
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

Y Yamane, and N Ishide, and Y Kagaya, and D Takeyama, and N Shiba, and M Chida, and T Nozaki, and T Takahashi, and T Ido, and K Shirato
Exacerbation of both ischemic and reperfusion damage by fatty acid in working rat hearts.
June 1994, Annals of the New York Academy of Sciences,
Y Yamane, and N Ishide, and Y Kagaya, and D Takeyama, and N Shiba, and M Chida, and T Nozaki, and T Takahashi, and T Ido, and K Shirato
Acute effects of triiodothyronine on glucose and fatty acid metabolism during reperfusion of ischemic rat hearts.
September 1998, The American journal of physiology,
Y Yamane, and N Ishide, and Y Kagaya, and D Takeyama, and N Shiba, and M Chida, and T Nozaki, and T Takahashi, and T Ido, and K Shirato
Fatty acid uptake in diabetic rat adipocytes.
February 1997, Molecular and cellular biochemistry,
Y Yamane, and N Ishide, and Y Kagaya, and D Takeyama, and N Shiba, and M Chida, and T Nozaki, and T Takahashi, and T Ido, and K Shirato
Salvianolic acid A demonstrates cardioprotective effects in rat hearts and cardiomyocytes after ischemia/reperfusion injury.
November 2011, Journal of cardiovascular pharmacology,
Y Yamane, and N Ishide, and Y Kagaya, and D Takeyama, and N Shiba, and M Chida, and T Nozaki, and T Takahashi, and T Ido, and K Shirato
Regulation of fatty acid utilization in isolated perfused rat hearts.
August 1973, The Journal of biological chemistry,
Y Yamane, and N Ishide, and Y Kagaya, and D Takeyama, and N Shiba, and M Chida, and T Nozaki, and T Takahashi, and T Ido, and K Shirato
Infarct-remodelled hearts with limited oxidative capacity boost fatty acid oxidation after conditioning against ischaemia/reperfusion injury.
February 2013, Cardiovascular research,
Y Yamane, and N Ishide, and Y Kagaya, and D Takeyama, and N Shiba, and M Chida, and T Nozaki, and T Takahashi, and T Ido, and K Shirato
Early and delayed protection by capsaicin against reperfusion injury in rat hearts.
October 1999, Zhongguo yao li xue bao = Acta pharmacologica Sinica,
Y Yamane, and N Ishide, and Y Kagaya, and D Takeyama, and N Shiba, and M Chida, and T Nozaki, and T Takahashi, and T Ido, and K Shirato
Ischemic preconditioning accelerates the fatty acid oxidation of rat hearts.
March 2009, International journal of cardiology,
Y Yamane, and N Ishide, and Y Kagaya, and D Takeyama, and N Shiba, and M Chida, and T Nozaki, and T Takahashi, and T Ido, and K Shirato
Metabolomics analysis in rat hearts with ischemia/reperfusion injury after diazoxide postconditioning.
January 2023, Frontiers in molecular biosciences,
Y Yamane, and N Ishide, and Y Kagaya, and D Takeyama, and N Shiba, and M Chida, and T Nozaki, and T Takahashi, and T Ido, and K Shirato
Trimetazidine improves recovery during reperfusion in isolated rat hearts after prolonged ischemia.
December 2003, Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology,
Copied contents to your clipboard!