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OBJECTIVE To evaluate a magnetic resonance (MR) imaging method for simultaneous assessment of gastric emptying and motility. METHODS Gastric emptying and motility were measured in nine volunteers after ingestion of a liquid meal. A specially designed MR imaging protocol was used that allowed simultaneous assessment of gastric emptying (spatial resolution, 1.5 mm; corrected for gastric secretion volume) and gastric motility (temporal resolution, 1.2 seconds; spatial resolution, 3.1 mm). To evaluate the ability to detect small changes in gastric motor activity with findings from this method, the influence of a prokinetic agent (loxiglumide) on gastric emptying and motility was tested in five volunteers. RESULTS Each contraction could be individually visualized at MR imaging. Administration of loxiglumide resulted in decreased gastric half-emptying time (mean +/- 1 standard error of the mean, 88.1 minutes +/- 6.3 for the placebo and 39.1 minutes +/- 6.7 for loxiglumide) and increased gastric motility (contraction frequency, 2.26 contractions per minute +/- 0.15 for the placebo and 3.04 per minute +/- 0.04 for loxiglumide). CONCLUSIONS MR imaging makes it feasible to study gastric emptying and gastric motility and to determine the influence of drugs on gastric motor activity.
P Kunz, and
G R Crelier, and
W Schwizer, and
J Borovicka, and
C Kreiss, and
M Fried, and
P Boesiger
March 2017,
Abdominal radiology (New York),
P Kunz, and
G R Crelier, and
W Schwizer, and
J Borovicka, and
C Kreiss, and
M Fried, and
P Boesiger
May 1995,
Archives of disease in childhood. Fetal and neonatal edition,
P Kunz, and
G R Crelier, and
W Schwizer, and
J Borovicka, and
C Kreiss, and
M Fried, and
P Boesiger
April 1982,
Revista medica de Chile,
P Kunz, and
G R Crelier, and
W Schwizer, and
J Borovicka, and
C Kreiss, and
M Fried, and
P Boesiger
January 2022,
Neurogastroenterology and motility,
P Kunz, and
G R Crelier, and
W Schwizer, and
J Borovicka, and
C Kreiss, and
M Fried, and
P Boesiger
December 1994,
Digestive diseases and sciences,
P Kunz, and
G R Crelier, and
W Schwizer, and
J Borovicka, and
C Kreiss, and
M Fried, and
P Boesiger
May 2000,
Radiology,
P Kunz, and
G R Crelier, and
W Schwizer, and
J Borovicka, and
C Kreiss, and
M Fried, and
P Boesiger
April 1998,
Radiology,
P Kunz, and
G R Crelier, and
W Schwizer, and
J Borovicka, and
C Kreiss, and
M Fried, and
P Boesiger
January 1999,
Radiology,
P Kunz, and
G R Crelier, and
W Schwizer, and
J Borovicka, and
C Kreiss, and
M Fried, and
P Boesiger
January 1987,
Gastroenterologie clinique et biologique,
P Kunz, and
G R Crelier, and
W Schwizer, and
J Borovicka, and
C Kreiss, and
M Fried, and
P Boesiger
July 1986,
Radiology,
