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It is known that calcium channel blockers induce Parkinsonism. In this study, amlodipine-, diltiazem-, and verapamil-induced catalepsy was investigated in mice. All of these three calcium channel blockers induced catalepsy. Dopamine D1, D2, and mACh receptor occupancies were estimated under the same conditions, and the affinities of these drugs for each receptor were also estimated in vitro. Intensity of catalepsy was predicted by dopamine D1, D2, and mACh receptor occupancies with the dynamic model which had already been constructed and was compared with the observed values. The predicted and the observed values were comparable (r = 0.98, p < 0.001). In conclusion, the dynamic model considering D1, and D2, and mACh receptor occupancy may be useful for quantitative prediction of drug-induced catalepsy.
K Haraguchi, and
K Ito, and
H Kotaki, and
Y Sawada, and
T Iga
February 1999,
Progress in neuro-psychopharmacology & biological psychiatry,
K Haraguchi, and
K Ito, and
H Kotaki, and
Y Sawada, and
T Iga
January 2000,
Acta poloniae pharmaceutica,
K Haraguchi, and
K Ito, and
H Kotaki, and
Y Sawada, and
T Iga
April 1996,
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics,
K Haraguchi, and
K Ito, and
H Kotaki, and
Y Sawada, and
T Iga
May 2004,
Acta pharmacologica Sinica,
K Haraguchi, and
K Ito, and
H Kotaki, and
Y Sawada, and
T Iga
January 1991,
Polish journal of pharmacology and pharmacy,
K Haraguchi, and
K Ito, and
H Kotaki, and
Y Sawada, and
T Iga
August 1994,
Medical hypotheses,
K Haraguchi, and
K Ito, and
H Kotaki, and
Y Sawada, and
T Iga
September 2011,
Journal of clinical hypertension (Greenwich, Conn.),
K Haraguchi, and
K Ito, and
H Kotaki, and
Y Sawada, and
T Iga
December 1995,
Clinical obstetrics and gynecology,
K Haraguchi, and
K Ito, and
H Kotaki, and
Y Sawada, and
T Iga
July 1982,
The Western journal of medicine,
K Haraguchi, and
K Ito, and
H Kotaki, and
Y Sawada, and
T Iga
February 1996,
CRNA : the clinical forum for nurse anesthetists,
