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The objective of the current study was to determine the effect of Yongdam-Sagan-Tang (YS-Tang) on the production of nitric oxide (NO). Stimulation of mouse peritoneal macrophages with YS-Tang after the treatment of recombinant interferon-gamma (rIFN-gamma) resulted in increased NO synthesis. YS-Tang had no effect on NO synthesis by itself. When YS-Tang was used in combination with rIFN-gamma, there was a marked co-operative induction of NO synthesis in a dose-dependent manner. The optimal effect of YS-Tang on NO synthesis was shown 6 h after treatment with rIFN-gamma. This increase in NO synthesis was reflected as an increased amount of inducible NO synthase (iNOS) protein. NO production was inhibited by NG-monomethyl-L-arginine. The increased production of NO from rIFN-gamma plus YS-Tang-stimulated cells was decreased by the treatment with staurosporin. In addition, synergy between rIFN-gamma and YS-Tang was mainly dependent on YS-Tang-induced tumor necrosis factor-alpha (TNF-alpha) secretion. All the preparations of YS-Tang were endotoxin free. These results suggest that the capacity of YS-Tang to increase NO production from rIFN-gamma-primed mouse peritoneal macrophages is the result of YS-Tang-induced TNF-alpha secretion.
E H Lee, and
N K Kim, and
C Y Hwang, and
H M Kim
June 1999,
General pharmacology,
E H Lee, and
N K Kim, and
C Y Hwang, and
H M Kim
April 2002,
Clinica chimica acta; international journal of clinical chemistry,
E H Lee, and
N K Kim, and
C Y Hwang, and
H M Kim
June 2007,
The Indian journal of medical research,
E H Lee, and
N K Kim, and
C Y Hwang, and
H M Kim
January 2002,
Fertility and sterility,
E H Lee, and
N K Kim, and
C Y Hwang, and
H M Kim
January 2014,
Mediators of inflammation,
E H Lee, and
N K Kim, and
C Y Hwang, and
H M Kim
October 1999,
Pharmacology & toxicology,
E H Lee, and
N K Kim, and
C Y Hwang, and
H M Kim
September 1999,
Hepatology (Baltimore, Md.),
E H Lee, and
N K Kim, and
C Y Hwang, and
H M Kim
November 1998,
Pancreas,
E H Lee, and
N K Kim, and
C Y Hwang, and
H M Kim
April 1992,
Science (New York, N.Y.),
E H Lee, and
N K Kim, and
C Y Hwang, and
H M Kim
November 2003,
Toxicology letters,
