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The expression of platelet-derived growth factor (PDGF) was studied in a rat model of Huntington's disease, produced by unilateral intrastriatal ibotenic acid injections. The most pronounced effect registered was that the number of PDGF-immunoreactive cells increased in the lesioned area up to 10 weeks after the surgery. Double immunofluorescence staining indicated that the PDGF-positive cells were astrocytes. The increased PDGF immunoreactivity was associated with only minor changes in total PDGF mRNA and PDGF protein levels in the lesioned area. Reverse transcription-polymerase chain reaction (RT-PCR) demonstrated a slight increase in PDGF mRNA after ibotenic acid lesion, but this was not reflected in an increase in PDGF A- and B-chain protein concentration as measured with ELISA. After sham operation an increase in PDGF protein concentration was seen, while the number of PDGF-immunoreactive cells was unchanged. The accumulation of PDGF in the astrocytes might reflect the role of PDGF in a repair process in neurodegenerative processes.
M Sjöborg, and
K Pietz, and
A Ahgren, and
N Yamada, and
O Lindvall, and
K Funa, and
P Odin
January 1993,
Cell transplantation,
M Sjöborg, and
K Pietz, and
A Ahgren, and
N Yamada, and
O Lindvall, and
K Funa, and
P Odin
November 2020,
Clinical laboratory,
M Sjöborg, and
K Pietz, and
A Ahgren, and
N Yamada, and
O Lindvall, and
K Funa, and
P Odin
April 2008,
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology,
M Sjöborg, and
K Pietz, and
A Ahgren, and
N Yamada, and
O Lindvall, and
K Funa, and
P Odin
March 1994,
Hepatology (Baltimore, Md.),
M Sjöborg, and
K Pietz, and
A Ahgren, and
N Yamada, and
O Lindvall, and
K Funa, and
P Odin
December 1993,
American journal of respiratory cell and molecular biology,
M Sjöborg, and
K Pietz, and
A Ahgren, and
N Yamada, and
O Lindvall, and
K Funa, and
P Odin
January 1995,
Annual review of physiology,
M Sjöborg, and
K Pietz, and
A Ahgren, and
N Yamada, and
O Lindvall, and
K Funa, and
P Odin
October 2008,
Laboratory investigation; a journal of technical methods and pathology,
M Sjöborg, and
K Pietz, and
A Ahgren, and
N Yamada, and
O Lindvall, and
K Funa, and
P Odin
January 1992,
Cancer research,
M Sjöborg, and
K Pietz, and
A Ahgren, and
N Yamada, and
O Lindvall, and
K Funa, and
P Odin
March 2014,
Zhonghua xin xue guan bing za zhi,
M Sjöborg, and
K Pietz, and
A Ahgren, and
N Yamada, and
O Lindvall, and
K Funa, and
P Odin
November 1988,
The Journal of biological chemistry,
