-transparent.png){kind=logo}
A marine natural product inhibitor of kinesin motors. 1998
R Sakowicz, and
M S Berdelis, and
K Ray, and
C L Blackburn, and
C Hopmann, and
D J Faulkner, and
L S Goldstein
Department of Pharmacology, Division of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0683, USA.
Members of the kinesin superfamily of motor proteins are essential for mitotic and meiotic spindle organization, chromosome segregation, organelle and vesicle transport, and many other processes that require microtubule-based transport. A compound, adociasulfate-2, was isolated from a marine sponge, Haliclona (also known as Adocia) species, that inhibited kinesin activity by targeting its motor domain and mimicking the activity of the microtubule. Thus, the kinesin-microtubule interaction site could be a useful target for small molecule modulators, and adociasulfate-2 should serve as an archetype for specific inhibitors of kinesin functions.
Related Publications
R Sakowicz, and
M S Berdelis, and
K Ray, and
C L Blackburn, and
C Hopmann, and
D J Faulkner, and
L S Goldstein
October 1997,
Current biology : CB,
R Sakowicz, and
M S Berdelis, and
K Ray, and
C L Blackburn, and
C Hopmann, and
D J Faulkner, and
L S Goldstein
January 2002,
Journal of chemical information and computer sciences,
R Sakowicz, and
M S Berdelis, and
K Ray, and
C L Blackburn, and
C Hopmann, and
D J Faulkner, and
L S Goldstein
January 2002,
Acta biochimica Polonica,
R Sakowicz, and
M S Berdelis, and
K Ray, and
C L Blackburn, and
C Hopmann, and
D J Faulkner, and
L S Goldstein
February 2002,
Inflammation research : official journal of the European Histamine Research Society ... [et al.],
R Sakowicz, and
M S Berdelis, and
K Ray, and
C L Blackburn, and
C Hopmann, and
D J Faulkner, and
L S Goldstein
December 2002,
Trends in cell biology,
R Sakowicz, and
M S Berdelis, and
K Ray, and
C L Blackburn, and
C Hopmann, and
D J Faulkner, and
L S Goldstein
August 2015,
Nature plants,
R Sakowicz, and
M S Berdelis, and
K Ray, and
C L Blackburn, and
C Hopmann, and
D J Faulkner, and
L S Goldstein
August 2006,
Biophysical chemistry,
R Sakowicz, and
M S Berdelis, and
K Ray, and
C L Blackburn, and
C Hopmann, and
D J Faulkner, and
L S Goldstein
February 2007,
Journal of molecular biology,
R Sakowicz, and
M S Berdelis, and
K Ray, and
C L Blackburn, and
C Hopmann, and
D J Faulkner, and
L S Goldstein
May 2005,
Nature,
R Sakowicz, and
M S Berdelis, and
K Ray, and
C L Blackburn, and
C Hopmann, and
D J Faulkner, and
L S Goldstein
September 2007,
European journal of cell biology,
