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A previous study of women who had died from myocardial infarction and of a control group of women matched with them for age suggested a fivefold increase in the risk of death from myocardial infarction among users of oral contraceptive aged 40-44 years compared with women not using such preparations. Only a small proportion of women in the infarction and control groups had used oral contraceptives, however, so the margin of error was wide. We therefore investigated a further 54 women in this age group who died from myocardial infarction and compared their oral contraceptive histories with those of age-matched, living controls. Combination of the findings from the present investigation with the previous results have enabled a revised estimate of a threefold increase in risk to be made. Although this risk estimate is similar to that previously shown for a younger age group, the total mortality attributable to complications associated with the use of oral contraceptives remained considerably greater among women over the age of 40.
J I Mann, and
W H Inman, and
M Thorogood
March 1998,
Contraception,
J I Mann, and
W H Inman, and
M Thorogood
September 1989,
International journal of epidemiology,
J I Mann, and
W H Inman, and
M Thorogood
April 1979,
Lancet (London, England),
J I Mann, and
W H Inman, and
M Thorogood
June 1990,
American journal of epidemiology,
J I Mann, and
W H Inman, and
M Thorogood
January 1980,
American journal of epidemiology,
J I Mann, and
W H Inman, and
M Thorogood
October 1997,
Community nurse,
J I Mann, and
W H Inman, and
M Thorogood
June 1999,
BMJ (Clinical research ed.),
J I Mann, and
W H Inman, and
M Thorogood
July 1971,
The American journal of cardiology,
J I Mann, and
W H Inman, and
M Thorogood
August 2007,
Fertility and sterility,
J I Mann, and
W H Inman, and
M Thorogood
November 1976,
Chest,
