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Experiments were carried out to study the events through which the process of endoreduplication occurs after treatment with colchicine in Chinese hamster cells cultivated in vitro, and to analyse the differences between the processes leading to normal mitosis and those leading to endoreduplication. Chinese hamster cells (line C-125) were treated with colchicine (10(-4) M) for 1 h, in order to induce endoreduplication. Before and after colchicine treatment the cultures were treated at various intervals with actinomycin D and puromycin. For preparation of mitosis specific RNA synthesis is required, and also synthesis of a specific protein, which is not required for endoreduplication. Moreover this suggests not only that the cells that endoreduplicate do not need new RNA and protein synthesis, but that inhibition of their synthesis apparently favours the processes of endoreduplication.
F Palitti, and
R Ricordy, and
P Perticone, and
S D'Andrea, and
M Rizzoni
March 1983,
Cancer research,
F Palitti, and
R Ricordy, and
P Perticone, and
S D'Andrea, and
M Rizzoni
November 1971,
Tsitologiia,
F Palitti, and
R Ricordy, and
P Perticone, and
S D'Andrea, and
M Rizzoni
March 1971,
Cancer research,
F Palitti, and
R Ricordy, and
P Perticone, and
S D'Andrea, and
M Rizzoni
April 1973,
Biology of reproduction,
F Palitti, and
R Ricordy, and
P Perticone, and
S D'Andrea, and
M Rizzoni
June 1993,
Idengaku zasshi,
F Palitti, and
R Ricordy, and
P Perticone, and
S D'Andrea, and
M Rizzoni
January 1984,
Doklady Akademii nauk SSSR,
F Palitti, and
R Ricordy, and
P Perticone, and
S D'Andrea, and
M Rizzoni
February 1978,
The Journal of experimental zoology,
F Palitti, and
R Ricordy, and
P Perticone, and
S D'Andrea, and
M Rizzoni
July 1984,
Genetika,
F Palitti, and
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P Perticone, and
S D'Andrea, and
M Rizzoni
November 1968,
Endocrinology,
F Palitti, and
R Ricordy, and
P Perticone, and
S D'Andrea, and
M Rizzoni
March 1983,
Mutation research,
