-transparent.png){kind=logo}
A series of new 1,3-disubstituted thieno[1,3-d]pyrimidine-2,4(1H,3H)-diones were prepared to investigate their analgesic and anti-inflammatory properties. The analgesic and anti-inflammatory activities of synthesized compounds were investigated by the phenylquinone-induced writhing syndrome test, carrageenan rat paw oedema test and acetic acid-induced peritonitis assay. Most of the new compounds were found to be superior to mefenamic acid, as they were devoid of any ulcerogenic activity.
Related Publications
G Romeo, and
F Russo, and
A Caruso, and
V Cutuli, and
M Amico-Roxas
January 2001,
Bollettino chimico farmaceutico,
G Romeo, and
F Russo, and
A Caruso, and
V Cutuli, and
M Amico-Roxas
August 2014,
Bioorganic & medicinal chemistry,
G Romeo, and
F Russo, and
A Caruso, and
V Cutuli, and
M Amico-Roxas
January 1988,
Annales pharmaceutiques francaises,
G Romeo, and
F Russo, and
A Caruso, and
V Cutuli, and
M Amico-Roxas
January 2009,
Molecules (Basel, Switzerland),
G Romeo, and
F Russo, and
A Caruso, and
V Cutuli, and
M Amico-Roxas
December 2007,
Acta pharmaceutica (Zagreb, Croatia),
G Romeo, and
F Russo, and
A Caruso, and
V Cutuli, and
M Amico-Roxas
December 2013,
Medicinal chemistry (Shariqah (United Arab Emirates)),
G Romeo, and
F Russo, and
A Caruso, and
V Cutuli, and
M Amico-Roxas
July 1989,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
G Romeo, and
F Russo, and
A Caruso, and
V Cutuli, and
M Amico-Roxas
March 2009,
Organic letters,
G Romeo, and
F Russo, and
A Caruso, and
V Cutuli, and
M Amico-Roxas
April 2009,
Acta crystallographica. Section C, Crystal structure communications,
G Romeo, and
F Russo, and
A Caruso, and
V Cutuli, and
M Amico-Roxas
November 2006,
European journal of medicinal chemistry,
