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The aim of the present study was to determine whether human endometrial cells are able to secrete beta-chorionic gonadotrophin (betaCG). Immunohistochemical studies and in-situ hybridization were performed in order to provide evidence for the occurrence of betaCG in the normal endometrium in 15 patients in the proliferative phase, two patients in the periovulatory phase and 13 patients in the secretory phase. Neither immunohistochemical nor hybridization reactions could be recognized during the proliferative phase. In contrast, both protein and betaCG mRNA were observed in the glandular cells of the endometrium during the secretory phase. The results were supported by Western blotting of secretory phase endometrium extracts and the assessment of the functional secretory capacity of primary endometrium cultures. In comparison with cultured and separated cell fractions, tissue extracts showed a higher betaCG, indicating a regulatory interaction. In conclusion, betaCG can be demonstrated in normal human cyclic endometrium, suggesting a paracrine role in endometrial physiology.
G W Wolkersdörfer, and
S R Bornstein, and
U Hilbers, and
G Zimmermann, and
C Biesold, and
M Lehmann, and
H Alexander
January 1989,
Journal of reproduction and fertility. Supplement,
G W Wolkersdörfer, and
S R Bornstein, and
U Hilbers, and
G Zimmermann, and
C Biesold, and
M Lehmann, and
H Alexander
May 2023,
Analytical biochemistry,
G W Wolkersdörfer, and
S R Bornstein, and
U Hilbers, and
G Zimmermann, and
C Biesold, and
M Lehmann, and
H Alexander
April 1999,
Journal of molecular endocrinology,
G W Wolkersdörfer, and
S R Bornstein, and
U Hilbers, and
G Zimmermann, and
C Biesold, and
M Lehmann, and
H Alexander
April 1980,
European journal of cancer,
G W Wolkersdörfer, and
S R Bornstein, and
U Hilbers, and
G Zimmermann, and
C Biesold, and
M Lehmann, and
H Alexander
March 1988,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
G W Wolkersdörfer, and
S R Bornstein, and
U Hilbers, and
G Zimmermann, and
C Biesold, and
M Lehmann, and
H Alexander
June 1986,
International journal of peptide and protein research,
G W Wolkersdörfer, and
S R Bornstein, and
U Hilbers, and
G Zimmermann, and
C Biesold, and
M Lehmann, and
H Alexander
September 1982,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
G W Wolkersdörfer, and
S R Bornstein, and
U Hilbers, and
G Zimmermann, and
C Biesold, and
M Lehmann, and
H Alexander
December 1996,
Journal of molecular endocrinology,
G W Wolkersdörfer, and
S R Bornstein, and
U Hilbers, and
G Zimmermann, and
C Biesold, and
M Lehmann, and
H Alexander
March 2017,
Yao xue xue bao = Acta pharmaceutica Sinica,
G W Wolkersdörfer, and
S R Bornstein, and
U Hilbers, and
G Zimmermann, and
C Biesold, and
M Lehmann, and
H Alexander
February 1984,
European journal of cancer & clinical oncology,
