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The time course of chronic diazepam effects on auditory evoked potentials was studied in rats. Auditory evoked potentials were elicited by background and target tones in a passive oddball paradigm. Diazepam was administered by slow release implants to establish constant blood concentrations. Recordings were made during 21 days of treatment and 9 days after treatment ceased. Diazepam increased the amplitude of the P40 component and decreased the amplitude of the P72-P102 components elicited by background tones. Diazepam increased the amplitude of the P40-P48 component and decreased that of the N58 component elicited by target tones. These effects remained constant during treatment. Diazepam further decreased the amplitude of the P102 component elicited by target tones. This effect became more distinct over time. No group differences were found 9 days after treatment. The constant drug effects on middle-latency components (P40-P48) might reflect diazepam-induced changes in sensory information processing. The decreased long-latency component (P102) might reflect a diminished attention to, or discrimination of, target tones. The time course of this effect might reflect diazepam-enhanced habituation.
M L Jongsma, and
C M Van Rijn, and
E A De Bruin, and
R Dirksen, and
A M Coenen
June 1968,
Journal of speech and hearing research,
M L Jongsma, and
C M Van Rijn, and
E A De Bruin, and
R Dirksen, and
A M Coenen
June 1990,
Neuropharmacology,
M L Jongsma, and
C M Van Rijn, and
E A De Bruin, and
R Dirksen, and
A M Coenen
January 2002,
Journal of vestibular research : equilibrium & orientation,
M L Jongsma, and
C M Van Rijn, and
E A De Bruin, and
R Dirksen, and
A M Coenen
November 2008,
Journal of psychopharmacology (Oxford, England),
M L Jongsma, and
C M Van Rijn, and
E A De Bruin, and
R Dirksen, and
A M Coenen
January 1987,
Experimental brain research,
M L Jongsma, and
C M Van Rijn, and
E A De Bruin, and
R Dirksen, and
A M Coenen
April 2004,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
M L Jongsma, and
C M Van Rijn, and
E A De Bruin, and
R Dirksen, and
A M Coenen
January 1988,
Electroencephalography and clinical neurophysiology,
M L Jongsma, and
C M Van Rijn, and
E A De Bruin, and
R Dirksen, and
A M Coenen
June 1999,
Journal of speech, language, and hearing research : JSLHR,
M L Jongsma, and
C M Van Rijn, and
E A De Bruin, and
R Dirksen, and
A M Coenen
January 1988,
Progress in neurobiology,
M L Jongsma, and
C M Van Rijn, and
E A De Bruin, and
R Dirksen, and
A M Coenen
September 1988,
Experimental neurology,
