BIOMAT Database Logo BIOMAT Database Logo

Successful treatment of a staphylococcal endocarditis vegetation with tissue plasminogen activator. 1998

R E Fleming, and S J Barenkamp, and S B Jureidini
Department of Pediatrics, St. Louis University School of Medicine, Missouri 63104, USA.

A 930 gm premature infant had Staphylococcal endocarditis with a tricuspid valvular vegetation that was unresponsive to antibiotics and not amenable to resection. Infusion of tissue plasminogen activator over a 3-day period completely lysed the vegetation. The infection cleared with continued antibiotics, and the infant recovered without sequelae.

UI MeSH Term Description Entries
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008297 Male Males
D010959 Tissue Plasminogen Activator A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases. Alteplase,Plasminogen Activator, Tissue-Type,T-Plasminogen Activator,Tissue-Type Plasminogen Activator,Actilyse,Activase,Lysatec rt-PA,TTPA,Tisokinase,Tissue Activator D-44,Lysatec rt PA,Lysatec rtPA,Plasminogen Activator, Tissue,Plasminogen Activator, Tissue Type,T Plasminogen Activator,Tissue Activator D 44,Tissue Type Plasminogen Activator
D010960 Plasminogen Activators A heterogeneous group of proteolytic enzymes that convert PLASMINOGEN to FIBRINOLYSIN. They are concentrated in the lysosomes of most cells and in the vascular endothelium, particularly in the vessels of the microcirculation. Extrinsic Plasminogen Activators,Plasminogen Activator,Uterine-Tissue Plasminogen Activator,Uterine Tissue Plasminogen Activator
D004452 Echocardiography Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic. Echocardiography, Contrast,Echocardiography, Cross-Sectional,Echocardiography, M-Mode,Echocardiography, Transthoracic,Echocardiography, Two-Dimensional,Transthoracic Echocardiography,2-D Echocardiography,2D Echocardiography,Contrast Echocardiography,Cross-Sectional Echocardiography,Echocardiography, 2-D,Echocardiography, 2D,M-Mode Echocardiography,Two-Dimensional Echocardiography,2 D Echocardiography,Cross Sectional Echocardiography,Echocardiography, 2 D,Echocardiography, Cross Sectional,Echocardiography, M Mode,Echocardiography, Two Dimensional,M Mode Echocardiography,Two Dimensional Echocardiography
D004697 Endocarditis, Bacterial Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use. Bacterial Endocarditides,Bacterial Endocarditis,Endocarditides, Bacterial
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D013203 Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS. Infections, Staphylococcal,Staphylococcus aureus Infection,Staphylococcal Infection,Staphylococcus aureus Infections

Related Publications

R E Fleming, and S J Barenkamp, and S B Jureidini
Successful treatment of infective endocarditis with recombinant tissue plasminogen activator.
November 2003, The Journal of pediatrics,
R E Fleming, and S J Barenkamp, and S B Jureidini
Treatment of infective endocarditis with recombinant tissue plasminogen activator.
January 2008, Pediatric blood & cancer,
R E Fleming, and S J Barenkamp, and S B Jureidini
Successful treatment of neonatal aortic thrombosis with tissue plasminogen activator.
May 1990, The Journal of pediatrics,
R E Fleming, and S J Barenkamp, and S B Jureidini
Successful treatment of neonatal arterial thromboses with recombinant tissue plasminogen activator.
July 1998, The Journal of pediatrics,
R E Fleming, and S J Barenkamp, and S B Jureidini
Successful treatment of fulminant pneumococcal sepsis with recombinant tissue plasminogen activator.
September 2002, European journal of internal medicine,
R E Fleming, and S J Barenkamp, and S B Jureidini
Successful treatment of haemolytic uraemic syndrome with recombinant tissue-type plasminogen activator.
June 1993, Lancet (London, England),
R E Fleming, and S J Barenkamp, and S B Jureidini
Successful treatment of aortic thrombosis after umbilical catheterization with tissue plasminogen activator.
November 1994, Acta paediatrica (Oslo, Norway : 1992),
R E Fleming, and S J Barenkamp, and S B Jureidini
Successful treatment of acute myocardial infarction during pregnancy with tissue plasminogen activator.
March 1997, American journal of obstetrics and gynecology,
R E Fleming, and S J Barenkamp, and S B Jureidini
Successful treatment of Candida albicans endocarditis vegetations with recombinant tissue plasminogen activator in an extremely low birth weight preterm infant.
September 2011, Mycoses,
R E Fleming, and S J Barenkamp, and S B Jureidini
Successful treatment for stroke in a child using recombinant tissue plasminogen activator.
August 2000, Journal of child neurology,
Copied contents to your clipboard!