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Rapid-onset dystonia-parkinsonism (RDP) is characterized by sudden onset over hours to days of dystonia, dysphagia, dysarthria, and parkinsonism. RDP has been reported by our group in two apparently unrelated families. We now report analysis of cerebrospinal fluid metabolites of dopamine, norepinephrine, and serotonin for mild and severely affected individuals, known asymptomatic gene carriers, and at-risk individuals from both families with RDP. Levels of the dopamine metabolite homovanillic acid (HVA) were decreased in severely affected patients and in some asymptomatic gene carriers. HVA levels increased with treatment in some affected individuals, but this increase did not predict clinical response to carbidopa/levodopa. We suggest that a low HVA level is a biological marker with modest association to the diagnosis of RDP.
A Brashear, and
I J Butler, and
K Hyland, and
M R Farlow, and
W B Dobyns
September 1969,
Life sciences,
A Brashear, and
I J Butler, and
K Hyland, and
M R Farlow, and
W B Dobyns
August 1988,
Annals of neurology,
A Brashear, and
I J Butler, and
K Hyland, and
M R Farlow, and
W B Dobyns
July 1974,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
A Brashear, and
I J Butler, and
K Hyland, and
M R Farlow, and
W B Dobyns
January 2005,
Przeglad lekarski,
A Brashear, and
I J Butler, and
K Hyland, and
M R Farlow, and
W B Dobyns
January 2011,
Handbook of clinical neurology,
A Brashear, and
I J Butler, and
K Hyland, and
M R Farlow, and
W B Dobyns
May 1992,
Acta neurologica Scandinavica,
A Brashear, and
I J Butler, and
K Hyland, and
M R Farlow, and
W B Dobyns
January 2006,
Journal of affective disorders,
A Brashear, and
I J Butler, and
K Hyland, and
M R Farlow, and
W B Dobyns
January 2008,
Revista de neurologia,
A Brashear, and
I J Butler, and
K Hyland, and
M R Farlow, and
W B Dobyns
May 2002,
Movement disorders : official journal of the Movement Disorder Society,
A Brashear, and
I J Butler, and
K Hyland, and
M R Farlow, and
W B Dobyns
March 2010,
Journal of neurology,
