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The effects of furosemide on urine flow, sodium and potassium excretion and on plasma renin activity (PRA) were studied in anesthetized rabbits with and without pretreatment with indomethacin 5 mg/kg. Furosemide caused a 10-fold increase in urine flow and in sodium excretion, and a 2-3 fold increase in PRA. Pretreatment with the prostaglandin synthesis inhibitor, indomethacin, reduced the effects of furosemide on diuresis and on electrolyte excretion by over 80% (p less than 0.01) and PRA did not increase over the initial level. The results suggest that the effects of furosemide on PRA and on urinary sodium excretion may be related to the intrarenal activation of the prostaglandin system.
E Oliw, and
G Kövér, and
C Larsson, and
E Anggård
October 1975,
Prostaglandins,
E Oliw, and
G Kövér, and
C Larsson, and
E Anggård
July 1980,
Archives of otolaryngology (Chicago, Ill. : 1960),
E Oliw, and
G Kövér, and
C Larsson, and
E Anggård
May 1983,
The Journal of the Kansas Medical Society,
E Oliw, and
G Kövér, and
C Larsson, and
E Anggård
March 1983,
The Journal of family practice,
E Oliw, and
G Kövér, and
C Larsson, and
E Anggård
December 1976,
Clinical science and molecular medicine. Supplement,
E Oliw, and
G Kövér, and
C Larsson, and
E Anggård
July 1977,
The Journal of clinical endocrinology and metabolism,
E Oliw, and
G Kövér, and
C Larsson, and
E Anggård
April 1975,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
E Oliw, and
G Kövér, and
C Larsson, and
E Anggård
July 1980,
European journal of pharmacology,
E Oliw, and
G Kövér, and
C Larsson, and
E Anggård
January 1984,
Arzneimittel-Forschung,
E Oliw, and
G Kövér, and
C Larsson, and
E Anggård
January 1977,
Pflugers Archiv : European journal of physiology,
