Excimer laser photorefractive keratectomy (PRK) is an effective treatment for myopia. We investigated the magnitude of optical zone decentration and qualitative patterns of corneal topography after this treatment. We performed computer-assisted videokeratography on 44 myopic eyes (29 patients) that had undergone PRK before and 1, 6, and 12 months after the procedure. Associations of clinical outcomes with decentration and topographic patterns were assessed. The normalized scale of the topography 1 month postoperatively showed a mean decentration of 0.33 +/- 0.23 mm (range 0-0.9). Thirty-four eyes had decentration of less than 0.50 mm; 10 had an ablation zone decentered from 0.5 to 0.9 mm. Analysis of geometric mean visual acuities between eyes with less than 0.5 mm decentration and those with 0.5 to 0.9 mm decentration demonstrated minimal differences. No eye was decentered more than 1 mm. Four main ablation patterns were noted on subtraction analysis: homogeneous, semicircular, keyhole, and central island. Over time, the number of eyes with a homogeneous pattern increased. Eyes with a homogeneous ablation pattern had significantly better uncorrected visual acuity than those with other patterns. The mean visual acuity was 20/29.1 in the homogeneous group and 20/38.5 in the pooled irregular group 1 month postoperatively (p < 0.05). There was no significant difference among the four ablation patterns at 6 or 12 months after PRK. Topographic patterns were not significantly associated with best-corrected vision.