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A 60-year-old HIV-seronegative man with a Mycobacterium avium pulmonary infection was treated with rifabutin, ethambutol and clarithromycin. He developed a serious arthritis which disappeared after interruption of the medication and recurred after resumption. The arthritis was attributed to the use of rifabutin. This adverse effect is more frequent with higher doses and in combination with the use of macrolide antibiotics.
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