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A sisomicin fermentation carried out in the presence of (methyl-14C)-L-methionine resulted in a crude mixture, composed of methyl-14C-labeled sisomicin as a major component; and two 4''-C-desmethylsisomicin (66-40B and 66-40D) isomer-like components, an unidentified component and a gentamicin A-like antibiotic as minor components. When (methyl-14C)-L-methionine was added in an early stage of the fermentation (24 hours), incorporation of methyl-14C-label into polar components (e.g., gentamicin A-like antibiotic) preceded that into sisomicin. Chromatographic evidence for the bioconversion of (methyl-14C)-gentamicin A to a radioactive sisomicin-like product (possibly (3''-N-methyl-14C)-sisomicin) was seen, when a Micromonospora blocked mutant was incubated in the presence of the former antibiotic.
B K Lee, and
R G Condon, and
G H Wagman, and
M J Weinstein, and
E Katz
September 1984,
The Journal of antibiotics,
B K Lee, and
R G Condon, and
G H Wagman, and
M J Weinstein, and
E Katz
June 1985,
Genetical research,
B K Lee, and
R G Condon, and
G H Wagman, and
M J Weinstein, and
E Katz
September 1998,
FEMS microbiology letters,
B K Lee, and
R G Condon, and
G H Wagman, and
M J Weinstein, and
E Katz
August 1990,
The Journal of antibiotics,
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R G Condon, and
G H Wagman, and
M J Weinstein, and
E Katz
January 2005,
Sheng wu gong cheng xue bao = Chinese journal of biotechnology,
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R G Condon, and
G H Wagman, and
M J Weinstein, and
E Katz
September 1985,
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology,
B K Lee, and
R G Condon, and
G H Wagman, and
M J Weinstein, and
E Katz
May 1974,
The Journal of organic chemistry,
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R G Condon, and
G H Wagman, and
M J Weinstein, and
E Katz
February 2024,
Applied biochemistry and biotechnology,
B K Lee, and
R G Condon, and
G H Wagman, and
M J Weinstein, and
E Katz
August 1990,
The Journal of antibiotics,
B K Lee, and
R G Condon, and
G H Wagman, and
M J Weinstein, and
E Katz
January 1967,
Antimicrobial agents and chemotherapy,
