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Numerous HLA studies suggest that genetic factors play an important role in the development of membranous nephropathy (MN). We studied seven patients with idiopathic MN, from three unrelated families of Italian ancestry. Complement phenotype analysis and restriction fragment length polymorphism (RFLP) typing of HLA class II and of the switch region genes were done in family members. In the first family, the father, one son, and one daughter had MN; another daughter had clinical glomerulonephritis. The three members with MN shared one HLA haplotype carrying DR beta 11; in the two siblings with the disease, the second HLA haplotype carried the DR beta 3.2 allele. In families 2 and 3, two brothers had MN: in family 2, they differed in at least one haplotype; in family 3, they differed in both haplotypes. Only family 3 was informative with regard to the RFLP of the switch region genes: the two siblings were identical for both Ig heavy chain haplotypes. No clinical, laboratory or morphologic features consistent with a secondary form of the disease were found. Familial clustering of MN suggests a genetically transmitted mechanism.
F Scolari, and
A Amoroso, and
S Savoldi, and
I Borelli, and
B Valzorio, and
E Costantino, and
M Bracchi, and
M Usberti, and
E Prati, and
R Maiorca
December 1984,
British medical journal (Clinical research ed.),
F Scolari, and
A Amoroso, and
S Savoldi, and
I Borelli, and
B Valzorio, and
E Costantino, and
M Bracchi, and
M Usberti, and
E Prati, and
R Maiorca
January 2008,
Nephron. Clinical practice,
F Scolari, and
A Amoroso, and
S Savoldi, and
I Borelli, and
B Valzorio, and
E Costantino, and
M Bracchi, and
M Usberti, and
E Prati, and
R Maiorca
March 1990,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
F Scolari, and
A Amoroso, and
S Savoldi, and
I Borelli, and
B Valzorio, and
E Costantino, and
M Bracchi, and
M Usberti, and
E Prati, and
R Maiorca
September 2021,
Nature reviews. Disease primers,
F Scolari, and
A Amoroso, and
S Savoldi, and
I Borelli, and
B Valzorio, and
E Costantino, and
M Bracchi, and
M Usberti, and
E Prati, and
R Maiorca
January 2010,
Nihon Jinzo Gakkai shi,
F Scolari, and
A Amoroso, and
S Savoldi, and
I Borelli, and
B Valzorio, and
E Costantino, and
M Bracchi, and
M Usberti, and
E Prati, and
R Maiorca
September 2021,
Nature reviews. Disease primers,
F Scolari, and
A Amoroso, and
S Savoldi, and
I Borelli, and
B Valzorio, and
E Costantino, and
M Bracchi, and
M Usberti, and
E Prati, and
R Maiorca
January 1997,
Ryoikibetsu shokogun shirizu,
F Scolari, and
A Amoroso, and
S Savoldi, and
I Borelli, and
B Valzorio, and
E Costantino, and
M Bracchi, and
M Usberti, and
E Prati, and
R Maiorca
November 2003,
La Revue du praticien,
F Scolari, and
A Amoroso, and
S Savoldi, and
I Borelli, and
B Valzorio, and
E Costantino, and
M Bracchi, and
M Usberti, and
E Prati, and
R Maiorca
September 1980,
The Journal of the Medical Society of New Jersey,
F Scolari, and
A Amoroso, and
S Savoldi, and
I Borelli, and
B Valzorio, and
E Costantino, and
M Bracchi, and
M Usberti, and
E Prati, and
R Maiorca
December 2013,
Nephrologie & therapeutique,
