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Serological testing for Lyme borreliosis was compared in 5 European reference laboratories with a total of 79 sera in order to determine variations in laboratory performance. A considerable range of methods were used and several laboratories employed 2 or 3 genomospecies of Borrelia burgdorferi sensu lato. No laboratory relied routinely on a single test and each weighted the significance of the findings of the various tests differently. A difference in strategy between laboratories in high and low prevalence areas was apparent in that laboratories in low prevalence areas emphasised specificity more than sensitivity and therefore produced fewer false positives, but also missed some cases. Overall agreement between the laboratories was poor and it was concluded that there is a need for a quality assurance scheme within Europe.
E C Guy, and
J N Robertson, and
M Cimmino, and
L Gern, and
Y Moosmann, and
S G Rijpkema, and
V Sambri, and
G Stanek
January 1988,
Annals of the New York Academy of Sciences,
E C Guy, and
J N Robertson, and
M Cimmino, and
L Gern, and
Y Moosmann, and
S G Rijpkema, and
V Sambri, and
G Stanek
March 1998,
Zentralblatt fur Bakteriologie : international journal of medical microbiology,
E C Guy, and
J N Robertson, and
M Cimmino, and
L Gern, and
Y Moosmann, and
S G Rijpkema, and
V Sambri, and
G Stanek
April 1994,
Journal of clinical pathology,
E C Guy, and
J N Robertson, and
M Cimmino, and
L Gern, and
Y Moosmann, and
S G Rijpkema, and
V Sambri, and
G Stanek
March 1998,
Zentralblatt fur Bakteriologie : international journal of medical microbiology,
E C Guy, and
J N Robertson, and
M Cimmino, and
L Gern, and
Y Moosmann, and
S G Rijpkema, and
V Sambri, and
G Stanek
January 2021,
Journal of microbiological methods,
E C Guy, and
J N Robertson, and
M Cimmino, and
L Gern, and
Y Moosmann, and
S G Rijpkema, and
V Sambri, and
G Stanek
January 1994,
Clinical and experimental rheumatology,
E C Guy, and
J N Robertson, and
M Cimmino, and
L Gern, and
Y Moosmann, and
S G Rijpkema, and
V Sambri, and
G Stanek
March 1996,
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,
E C Guy, and
J N Robertson, and
M Cimmino, and
L Gern, and
Y Moosmann, and
S G Rijpkema, and
V Sambri, and
G Stanek
November 1992,
Journal of clinical epidemiology,
E C Guy, and
J N Robertson, and
M Cimmino, and
L Gern, and
Y Moosmann, and
S G Rijpkema, and
V Sambri, and
G Stanek
February 1993,
Journal of clinical microbiology,
E C Guy, and
J N Robertson, and
M Cimmino, and
L Gern, and
Y Moosmann, and
S G Rijpkema, and
V Sambri, and
G Stanek
June 2011,
Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne,
