BIOMAT Database Logo BIOMAT Database Logo

Lung reperfusion injury after chronic or acute unilateral pulmonary artery occlusion. 1998

E Fadel, and G M Mazmanian, and A Chapelier, and B Baudet, and H Detruit, and V de Montpreville, and J M Libert, and M Wartski, and P Herve, and P Dartevelle
Laboratoire de Chirurgie Experimentale, Centre Chirurgical Marie Lannelongue, Université Paris Sud, Le Plessis Robinson, France.

Because the lungs receive their blood supply from both the pulmonary and bronchial systems, chronic pulmonary artery obstruction does not necessarily result in severe ischemia. Ischemia-reperfusion (IR) lung injury may therefore be attenuated after long-term pulmonary artery obstruction. To test this hypothesis, isolated left lungs of pigs were reperfused two days (acute IR group) or 5 wk (chronic IR group) after left pulmonary artery ligation and compared to those of sham-operated animals. The severity of IR-lung injury after 60 min ex vivo reperfusion of the left lung was assessed based on lung histology and measurements of filtration coefficient (Kfc), pulmonary arterial resistance (Rpa), and lung myeloperoxidase (MPO) activity. Marked bronchial circulation hypertrophy was seen in the chronic IR group. Hemorrhagic alveolar edema was found in all acute IR lungs but not in sham or chronic IR lungs. Compared with the sham-operated controls, Kfc and Rpa increased two-fold and threefold, and MPO 1.5-fold and twofold in the chronic and acute IR groups, respectively. In conclusion, IR-induced lung injury was markedly reduced when it occurred 5 wk after pulmonary artery ligation, probably because the systemic blood supply to the lung had time to develop, limiting ischemia.

UI MeSH Term Description Entries
D007958 Leukocyte Count The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells. Blood Cell Count, White,Differential Leukocyte Count,Leukocyte Count, Differential,Leukocyte Number,White Blood Cell Count,Count, Differential Leukocyte,Count, Leukocyte,Counts, Differential Leukocyte,Counts, Leukocyte,Differential Leukocyte Counts,Leukocyte Counts,Leukocyte Counts, Differential,Leukocyte Numbers,Number, Leukocyte,Numbers, Leukocyte
D008026 Ligation Application of a ligature to tie a vessel or strangulate a part. Ligature,Ligations,Ligatures
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D009195 Peroxidase A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7. Myeloperoxidase,Hemi-Myeloperoxidase,Hemi Myeloperoxidase
D009504 Neutrophils Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. LE Cells,Leukocytes, Polymorphonuclear,Polymorphonuclear Leukocytes,Polymorphonuclear Neutrophils,Neutrophil Band Cells,Band Cell, Neutrophil,Cell, LE,LE Cell,Leukocyte, Polymorphonuclear,Neutrophil,Neutrophil Band Cell,Neutrophil, Polymorphonuclear,Polymorphonuclear Leukocyte,Polymorphonuclear Neutrophil
D011651 Pulmonary Artery The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs. Arteries, Pulmonary,Artery, Pulmonary,Pulmonary Arteries
D011652 Pulmonary Circulation The circulation of the BLOOD through the LUNGS. Pulmonary Blood Flow,Respiratory Circulation,Circulation, Pulmonary,Circulation, Respiratory,Blood Flow, Pulmonary,Flow, Pulmonary Blood,Pulmonary Blood Flows
D002199 Capillary Permeability The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement. Microvascular Permeability,Permeability, Capillary,Permeability, Microvascular,Vascular Permeability,Capillary Permeabilities,Microvascular Permeabilities,Permeabilities, Capillary,Permeabilities, Microvascular,Permeabilities, Vascular,Permeability, Vascular,Vascular Permeabilities
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013552 Swine Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA). Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog

Related Publications

E Fadel, and G M Mazmanian, and A Chapelier, and B Baudet, and H Detruit, and V de Montpreville, and J M Libert, and M Wartski, and P Herve, and P Dartevelle
Reperfusion lung injury after unilateral pulmonary artery occlusion.
June 2000, Respirology (Carlton, Vic.),
E Fadel, and G M Mazmanian, and A Chapelier, and B Baudet, and H Detruit, and V de Montpreville, and J M Libert, and M Wartski, and P Herve, and P Dartevelle
Injury in nonischemic lung after unilateral pulmonary ischemia with reperfusion.
February 1992, Journal of applied physiology (Bethesda, Md. : 1985),
E Fadel, and G M Mazmanian, and A Chapelier, and B Baudet, and H Detruit, and V de Montpreville, and J M Libert, and M Wartski, and P Herve, and P Dartevelle
Pulmonary edema after pulmonary artery occlusion and reperfusion.
November 1989, The American review of respiratory disease,
E Fadel, and G M Mazmanian, and A Chapelier, and B Baudet, and H Detruit, and V de Montpreville, and J M Libert, and M Wartski, and P Herve, and P Dartevelle
Microvascular injury distal to unilateral pulmonary artery occlusion.
October 1981, Journal of applied physiology: respiratory, environmental and exercise physiology,
E Fadel, and G M Mazmanian, and A Chapelier, and B Baudet, and H Detruit, and V de Montpreville, and J M Libert, and M Wartski, and P Herve, and P Dartevelle
Delayed lung lesions after six hours' unilateral pulmonary artery occlusion in dogs.
January 1970, Scandinavian journal of thoracic and cardiovascular surgery,
E Fadel, and G M Mazmanian, and A Chapelier, and B Baudet, and H Detruit, and V de Montpreville, and J M Libert, and M Wartski, and P Herve, and P Dartevelle
Pulmonary haemodynamics and blood gases during unilateral pulmonary artery occlusion and after lung resection.
January 1970, Bulletin de physio-pathologie respiratoire,
E Fadel, and G M Mazmanian, and A Chapelier, and B Baudet, and H Detruit, and V de Montpreville, and J M Libert, and M Wartski, and P Herve, and P Dartevelle
Changes in regional lung mechanics and ventilation distribution after unilateral pulmonary artery occlusion.
March 1997, Journal of applied physiology (Bethesda, Md. : 1985),
E Fadel, and G M Mazmanian, and A Chapelier, and B Baudet, and H Detruit, and V de Montpreville, and J M Libert, and M Wartski, and P Herve, and P Dartevelle
PentaLyte decreases lung injury after aortic occlusion-reperfusion.
June 1998, American journal of respiratory and critical care medicine,
E Fadel, and G M Mazmanian, and A Chapelier, and B Baudet, and H Detruit, and V de Montpreville, and J M Libert, and M Wartski, and P Herve, and P Dartevelle
Lung reperfusion injury in patients after balloon angioplasty for pulmonary artery stenosis.
June 2014, Journal of cardiothoracic and vascular anesthesia,
E Fadel, and G M Mazmanian, and A Chapelier, and B Baudet, and H Detruit, and V de Montpreville, and J M Libert, and M Wartski, and P Herve, and P Dartevelle
Experimental unilateral pulmonary artery occlusion. Acute and chronic effects on relative inhalation and perfusion.
January 1972, Radiology,
Copied contents to your clipboard!