BIOMAT Database Logo BIOMAT Database Logo

Elevated fetal fibronectin in midtrimester amniotic fluid is involved with the onset of preeclampsia. 1998

M Sakura, and M Nakabayashi, and Y Takeda, and K Sato
Department of Obstetrics and Gynaecology, Tokyo Women's Medical College, Japan.

OBJECTIVE To examine early midtrimester amniotic fluid for its significance in pregnancy outcomes, especially with connection to the pathogenesis of preeclampsia. METHODS A prospective, nested, case-control study was conducted. Fetal fibronectin in early midtrimester (16-20 weeks gestation) amniotic fluid was measured by EIA method. Results were compared by their pregnancy outcomes. RESULTS Amniotic fluid levels of fetal fibronectin were significantly higher in the group subsequently developing severe preeclampsia (106.8 +/- 13.2 micrograms/ml, mean +/- SD, n = 12) compared with matched controls (66.7 +/- 7.1 micrograms/ml, n = 12) (p < 0.05). CONCLUSIONS High levels of fetal fibronectin were found in the amniotic fluid of women subsequently developing severe preeclampsia before any symptom appear. Involvement of extracellular injury or cellular hyperactivity in the midtrimester placental site with the onset of preeclampsia is suggested.

UI MeSH Term Description Entries
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007236 Infant, Small for Gestational Age An infant having a birth weight lower than expected for its gestational age.
D011225 Pre-Eclampsia A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease. Toxemias, Pregnancy,EPH Complex,EPH Gestosis,EPH Toxemias,Edema-Proteinuria-Hypertension Gestosis,Gestosis, EPH,Hypertension-Edema-Proteinuria Gestosis,Preeclampsia,Preeclampsia Eclampsia 1,Pregnancy Toxemias,Proteinuria-Edema-Hypertension Gestosis,Toxemia Of Pregnancy,1, Preeclampsia Eclampsia,1s, Preeclampsia Eclampsia,EPH Toxemia,Eclampsia 1, Preeclampsia,Eclampsia 1s, Preeclampsia,Edema Proteinuria Hypertension Gestosis,Gestosis, Edema-Proteinuria-Hypertension,Gestosis, Hypertension-Edema-Proteinuria,Gestosis, Proteinuria-Edema-Hypertension,Hypertension Edema Proteinuria Gestosis,Of Pregnancies, Toxemia,Of Pregnancy, Toxemia,Pre Eclampsia,Preeclampsia Eclampsia 1s,Pregnancies, Toxemia Of,Pregnancy Toxemia,Pregnancy, Toxemia Of,Proteinuria Edema Hypertension Gestosis,Toxemia Of Pregnancies,Toxemia, EPH,Toxemia, Pregnancy,Toxemias, EPH
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011256 Pregnancy Outcome Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; or SPONTANEOUS ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO. Outcome, Pregnancy,Outcomes, Pregnancy,Pregnancy Outcomes
D011262 Pregnancy Trimester, Second The middle third of a human PREGNANCY, from the beginning of the 15th through the 28th completed week (99 to 196 days) of gestation. Midtrimester,Pregnancy, Second Trimester,Trimester, Second,Midtrimesters,Pregnancies, Second Trimester,Pregnancy Trimesters, Second,Second Pregnancy Trimester,Second Pregnancy Trimesters,Second Trimester,Second Trimester Pregnancies,Second Trimester Pregnancy,Second Trimesters,Trimesters, Second
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D001724 Birth Weight The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms. Birthweight,Birth Weights,Birthweights,Weight, Birth,Weights, Birth
D002585 Cesarean Section Extraction of the FETUS by means of abdominal HYSTEROTOMY. Abdominal Delivery,Delivery, Abdominal,C-Section (OB),Caesarean Section,Postcesarean Section,Abdominal Deliveries,C Section (OB),C-Sections (OB),Caesarean Sections,Cesarean Sections,Deliveries, Abdominal
D005260 Female Females

Related Publications

M Sakura, and M Nakabayashi, and Y Takeda, and K Sato
Matrix metalloproteinase-2 is elevated in midtrimester amniotic fluid prior to the development of preeclampsia.
August 2009, Reproductive biology and endocrinology : RB&E,
M Sakura, and M Nakabayashi, and Y Takeda, and K Sato
Fetal fibronectin levels are elevated in maternal plasma and amniotic fluid of patients with severe preeclampsia.
February 1995, American journal of obstetrics and gynecology,
M Sakura, and M Nakabayashi, and Y Takeda, and K Sato
Tumor necrosis factor-alpha in midtrimester amniotic fluid is associated with impaired intrauterine fetal growth.
October 1992, American journal of obstetrics and gynecology,
M Sakura, and M Nakabayashi, and Y Takeda, and K Sato
A bias away from Th2 in amniotic fluid is involved in preeclampsia.
August 2022, Journal of reproductive immunology,
M Sakura, and M Nakabayashi, and Y Takeda, and K Sato
Testosterone levels in midtrimester maternal and fetal plasma and amniotic fluid.
January 1985, Prenatal diagnosis,
M Sakura, and M Nakabayashi, and Y Takeda, and K Sato
Fetal fibronectin concentration in amniotic fluid decreases with advancing gestational age.
April 1995, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
M Sakura, and M Nakabayashi, and Y Takeda, and K Sato
Tumor necrosis factor-alpha is elevated in plasma and amniotic fluid of patients with severe preeclampsia.
June 1994, American journal of obstetrics and gynecology,
M Sakura, and M Nakabayashi, and Y Takeda, and K Sato
Elevated amniotic fluid alpha fetoprotein in fetal hydrocephaly.
May 1974, American journal of obstetrics and gynecology,
M Sakura, and M Nakabayashi, and Y Takeda, and K Sato
Amniotic fluid fibronectin and the synthesis of fibronectin by amniotic fluid cells in culture.
June 1978, Annals of the New York Academy of Sciences,
M Sakura, and M Nakabayashi, and Y Takeda, and K Sato
Midtrimester amniotic fluid adiponectin in normal pregnancy.
September 2007, Clinical chemistry,
Copied contents to your clipboard!